Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14349 |
Auristatin F
|
Microtubule Associated | Cytoskeletal Signaling |
Auristatin F 是一种有效的微管抑制剂和血管损伤剂。 Auristatin F 可用于抗体-药物偶联物。 | |||
T3256 |
MMAF
一甲基澳瑞他汀 F,MonoMethyl auristatin F |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
MMAF (MonoMethyl auristatin F) 是一种抗有丝分裂剂,通过阻断微管蛋白的聚合来抑制细胞分裂,用作抗肿瘤药物和抗体偶联药物的细胞毒性成分。 | |||
T12081 |
MMAF-OMe
Monomethyl auristatin F methyl ester |
||
MMAF-OMe (Monomethyl auristatin F methyl ester) 是一种抗微管蛋白剂,能够抑制 MDAMB435/5T4,MDAMB361DYT2,MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞,IC50值分别为 0.056 nM,0.166 nM,0.183 nM 和 0.449 nM。它也是ADC 细胞毒素。 | |||
T18251 |
MAL-di-EG-Val-Cit-PAB-MMAF
|
Others | Others |
MAL-di-EG-Val-Cit-PAB-MMAF refers to a chemical compound that comprises the linker (MAL-di-EG-Val-Cit-PAB) and the potent blocker of tubulin polymerization (MMAF, Monomethyl auristatin F)[1]. | |||
T18326 |
MC-Val-Cit-PAB-MMAF
|
Others | Others |
MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB. | |||
T27975 |
MAL-PEG4-MMAF
|
||
MAL-PEG4-MMAF is a maleimido functionalized derivative of MMAF (Monomethyl auristatin F) with PEG4 linker. The maleimido functional group can be easily conjugated to protein carriers (such as antibody or enzyme). MAL-PEG4-MMAF is a useful precursor for ma | |||
T77892 |
Mal-PEG8-Val-Cit-PAB-MMAF
|
||
Mal-PEG8-Val-Cit-PAB-MMAF 是一种用于抗体药物偶联体 (ADC) 的药物-连接物复合体 (drug-linker conjugate for ADC)。该化合物由一个可降解的 ADC linker 以及有效的微管蛋白抑制剂 MMAE 组成。 | |||
T77894 |
Val-Cit-PAB-MMAF sodium
|
||
Val-Cit-PAB-MMAFsodium为抗体药物偶联物(ADC)的活性组分,其结构由ADC连接子(肽类连接子Val-Cit-PAB)与高效微管蛋白聚合抑制剂MMAF通过偶联形成。 |