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Cat. No. | Product Name | Target | Signaling Pathways |
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T72191 |
Antiproliferative agent-20
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Antiproliferative agent-20,一种具有口服活性的有效抗癌剂,展现出抗增殖及抗血管生成活性。 | |||
T73460 |
DDO3711
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DDO3711是通过化学接头将ASK1 (小分子凋亡信号调节激酶1) 抑制剂与PP5 (磷酸酶) 激活剂连接,形成特定于招募PP5的磷酸酶募集嵌合体(PHORC)。该化合物特异性地抑制ASK1 (IC50=164.1 nM),而对ASK2 (IC50>20 μM)无影响。通过募集PP5,DDO3711显著促进p-ASK1T838的去磷酸化,表现出ASK1依赖性的抗增殖活性,显示其抗癌潜力并可用于研究异常磷酸化癌蛋白。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. |