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21

抑制剂 & 化合物

7

天然产物

1

同位素

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Cat. No.	Product Name	Target	Signaling Pathways
T60963	Antimicrobial agent-2
	Antimicrobial agent-2 (compound V-a) 是对多种革兰氏阳性和革兰氏阴性菌均有抑制作用，是一种低毒、无明显耐药性、生物利用度好的广谱抗菌剂。Antimicrobial agent-2 有效破坏细胞膜，并导致蛋白渗出，诱导活性氧的产生。Antimicrobial agent-2 可有效抑制耐甲氧西林金黄色葡萄球菌 (MRSA)，MIC 为 1 μg/mL。
T77700	2-Butyl-1,2-benzisothiazolin-3-one 2-butylbenzo[d]isothiazol-3(2H)-one	Antifungal	Microbiology/Virology
	2-Butyl-1,2-benzisothiazolin-3-one 是一种可口服的抗菌剂，具有抗菌活性，常见于制药专业和食品加工。
T11427	Antibacterial compound 2	Antifungal	Microbiology/Virology
	Antibacterial compound 2 是一种有效的抗菌剂，对许多人类兽医病原体有效，对多重耐药葡萄球菌、肠球菌和链球菌，以及厌氧菌有抑制作用。
T77608	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-	Antifungal	Microbiology/Virology
	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 可作为一种广谱抗菌剂，对黑曲霉枯草芽孢杆菌、白假丝酵母、大肠杆菌和金黄色葡萄球菌有抑制作用。1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 在体外实验中显示出抗炎活性，可用于治疗细菌感染。
T74967	Antimicrobial agent-11
	Antimicrobial agent-11 是一种 SARS-CoV-2 抑制剂，同时具有抗菌活性。
T74966	Antimicrobial agent-10
	Antimicrobial agent-10 是一种 SARS-CoV-2 抑制剂，具有良好的抗菌活性。
T74968	Antimicrobial agent-12
	Antimicrobial agent-12 是一种有效的抗菌剂，同时具有 SARS-CoV-2 抑制活性。
T29527	ABT-255 ABT 255,ABT255,UNII-YA04O24J4T
	ABT-255 is a novel 2-pyridone antimicrobial agent for the treatment of tuberculosis. Both drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis showed efficacy in vitro and in vivo.
T61783	Antimicrobial agent-1
	Antimicrobial Agent-1 (compound 6C) shows strong activity (MIC = 2 μg/mL) against TolC mutant E. coli. Additionally, it synergistically interacts with Colistin to exhibit enhanced activity against Gram-negative bacteria. Importantly, Antimicrobial Agent-1 exhibits no cytotoxic effects on mammalian cell lines. Its MIC values on Caco-2 and Vero cell lines are greater than 128 μg/mL [1].
T72414	Antimicrobial agent-8
	Antimicrobial agent-8 是一种有效的抗菌剂，对革兰氏阴性和革兰氏阳性菌表现出强大的抗菌活性，MIC 范围为 2-8 μg/mL。Antimicrobial agent-8 对脂多糖引起的炎症表现出抗炎活性。
T29531	ABT-719 HCl A-816719.1,A 816719.1,ABT-719,ABT719,ABT 719,ABT-719 hydrochloride
	ABT-719 is a 2-pyridinone antimicrobial agent that is more effective against Enterococcus faecalis strains than ciprofloxacin and vancomycin, which showed resistance to ciprofloxacin and vancomycin covering a range of MIC.
T10243	Ibezapolstat ACX-362E	Others	Others
	ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections (MIC50: 2 μg/mL for C. difficile).
T74953	Antimicrobial agent-7
	Antimicrobial agent-7 (Compound 12) 为一化合物，对革兰氏阴性及革兰氏阳性菌展现出显著的抗菌能力，MIC值介于 2-8 μg/mL 之间。此外，该化合物还对脂多糖引发的炎症有着抗炎作用。
T38915	Antibacterial agent 32
	Antibacterial agent 32 exhibits potent antimicrobial activity against E. coli strains NCTC 13351, M 50, and 7 MP, with minimum inhibitory concentration (MIC) values of 1 mcg/mL, 2 mcg/mL, and 8 mcg/mL, respectively (WO2013030733A1, example 43).
T74954	Antimicrobial agent-9
	Antimicrobial agent-9 (Compound 16) 作为一种抗菌剂，其对革兰氏阳性及革兰氏阴性细菌表现出2-8 μg/mL的最小抑菌浓度（MIC）。此外，Antimicrobial agent-9 还展现了抗炎活性。
T9791	Mequindox
	Mequindox(MEQ) 是一种抗菌剂。Mequindox 作为DNA 合成的抑制剂，对小鼠具有遗传毒性和致癌性。
T35680	2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide
	2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is an antimicrobial agent.1It is active against the Gram-negative bacteriaE. coli,P. aeruginosa, andS. marcescens(MICs = 64, 100, and 70 μg/ml, respectively), the Gram-positive bacteriaS. aureus,M. luteus, andB. cereus(MICs = 130, 100, and 50 μg/ml, respectively), and the fungiC. albicans,G. candidum,T. rubrum,F. oxysporum,A. flavus, andS. brevicaulis(MICs = 69-120 μg/ml). 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is also a prec...
T64971	Sodium diacetate Acetic acid, sodium salt (2:1)	Others	Others
	Sodium diacetate (Acetic acid, sodium salt (2:1)) 是一种醋酸盐。它是一种无色固体，用于调味料和抗菌剂。作为一种新型的粮食、饮料食品添加剂，在食品添加剂中得到了广泛的应用。
T73659	HLF1-11
	HLF1-11，一种人乳铁蛋白衍生肽，是一种广谱抗菌剂。HLF1-11 抑制MPO(human) 的活性。HLF1-11 还使GM-CSF 驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。
T75317	Vitamin K5
	Vitamin K5，一种光敏剂，对细菌和真菌展现出强效抗菌特性。作为PKM2的特异性抑制剂，其对PKM2、PKM1及PKL的IC50值分别为28、191和120 μM。此外，Vitamin K5能诱导colon 26细胞进入凋亡。因其具备的这些性质，Vitamin K5在感染和癌症研究中有应用，并可作为药品、食品和饮料的防腐剂。
T37741	N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which...

化合物

Antimicrobial agent-2

Cat.No: T60963

2-Butyl-1,2-benzisothiazolin-3-one

Cat.No: T77700

Synonym: 2-butylbenzo[d]isothiazol-3(2H)-one

Target: Antifungal

Antibacterial compound 2

Cat.No: T11427

Target: Antifungal

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-

Cat.No: T77608

Target: Antifungal

Antimicrobial agent-11

Cat.No: T74967

Antimicrobial agent-10

Cat.No: T74966

Antimicrobial agent-12

Cat.No: T74968

Cat.No: T29527

Synonym: ABT 255,ABT255,UNII-YA04O24J4T

Antimicrobial agent-1

Cat.No: T61783

Antimicrobial agent-8

Cat.No: T72414

Cat.No: T29531

Synonym: A-816719.1,A 816719.1,ABT-719,ABT719,ABT 719,ABT-719 hydrochloride

Cat.No: T10243

Synonym: ACX-362E

Target: Others

Antimicrobial agent-7

Cat.No: T74953

Antibacterial agent 32

Cat.No: T38915

Antimicrobial agent-9

Cat.No: T74954

Cat.No: T9791

2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide

Cat.No: T35680

Sodium diacetate

Cat.No: T64971

Synonym: Acetic acid, sodium salt (2:1)

Target: Others

Cat.No: T73659

Cat.No: T75317

N-hexadecanoyl-L-Homoserine lactone

Cat.No: T37741

Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone

Cat. No.	Product Name	Target	Signaling Pathways
T20587	2-Acetonaphthone 2-萘乙酮,beta-Acetylnaphthalene,beta-Acetonaphthalene,2Acetylnaphthalene,2-Acetylnaphthalene,2 Acetylnaphthalene,beta-Naphthyl methyl ketone	Endogenous Metabolite	Metabolism
	2-Acetonaphthone (beta-Naphthyl methyl ketone) 是内源性代谢产物的一种。
T4861	trans-Aconitic acid	ATPase; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	trans-Aconitic acid 是反式丙酮酸2-甲基转移酶的底物，存在于正常人尿液中，大量存在于 Reye 综合征和有机酸尿症。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T38241	2-Aminoimidazole
	2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. Additionally, 2-Aminoimidazole acts as a weak noncompetitive inhibitor of human arginase I, with a Ki value of 3.6 mM[1][2][3].
T80331	XT-2 peptide
	XT-2 peptide, 源自热带爪蟾(Xenopus tropicalis)皮肤分泌物的抗菌肽，具有强效抗E.coli活性，其最小抑菌浓度(MIC)为8 μM。
T77242	Pectin
	Pectin是从高等植物细胞壁中提取的一种杂多糖。作为纳米颗粒制备，它用作活性分子的运载载体。此外，Pectin还具有吸附剂和广谱抗菌剂的功能，能够结合肠道粘膜中的细菌毒素及其他刺激物，从而缓解受刺激的黏膜。

天然产物

2-Acetonaphthone

Cat.No: T20587

Synonym: 2-萘乙酮,beta-Acetylnaphthalene,beta-Acetonaphthalene,2Acetylnaphthalene,2-Acetylnaphthalene,2 Acetylnaphthalene,beta-Naphthyl methyl ketone

Target: Endogenous Metabolite

trans-Aconitic acid

Cat.No: T4861

Target: ATPase, Endogenous Metabolite

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

2-Aminoimidazole

Cat.No: T38241

Cat.No: T80331

Cat.No: T77242

Cat. No.	Product Name	Target	Signaling Pathways
T69995	Chlorhexidine-d8 HCl
	Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC...

同位素

Chlorhexidine-d8 HCl

Cat.No: T69995

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