Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62057 | Anticancer agent 12 | ||
Anticancer agent 12 具有恶性细胞的细胞毒性,且没有肝毒性。 | |||
T60776 |
Anticancer agent 68
|
||
Anticancer agent 68 is (Compound 12) 是一种抗癌剂。Anticancer agent 68 将细胞阻滞在 G2/M 期并诱导程序性细胞死亡。Anticancer agent 68 通过激活 p53 和 PTEN 诱导上调肿瘤抑制。 | |||
T78929 |
Anticancer agent 126
|
Histone Methyltransferase | Chromatin/Epigenetic |
Anticanceragent 126 (compound 12) 作为WDR5抑制剂,能够破坏WDR5-MYC间的相互作用,并降低MYC靶基因的表达,表现出其抗癌活性。 | |||
T79247 |
Anticancer agent 127
|
IAP | Apoptosis |
Anticanceragent 127 (142D6) 是一种共价靶向 XIAP、cIAP1 以及 cIAP2 的 BIR3 结构域的IAP抑制剂,其对 XIAP、cIAP1 和 cIAP2 的 BIR3 结构域的 IC50 值分别为 12 nM、14 nM 和 9 nM,显示出抗癌活性。 | |||
T83786 |
8-Chloroadenosine-5'-triphosphate sodium
8-chloro ATP |
||
8-Chloroadenosine-5’-triphosphate(8-chloro ATP)是抗癌剂8-chloro cAMP的活性代谢物,也是核苷酸腺苷5’-三磷酸(ATP)的衍生物。它通过8-chloro cAMP、8-chloroadenosine以及一磷酸和二磷酸中间体形成。应用8-chloro cAMP或8-chloroadenosine后,8-chloro ATP可累积长达12小时,与细胞生长抑制、内源性ATP水平下降以及患者源多发性骨髓瘤细胞中RNA合成减少(但DNA合成不受影响)相关。在1.5至8 mM浓度范围内,它抑制topoisomerase II-α依赖的超螺旋pUC19 DNA放松,同时在1 mM时减少了K562人髓性白血病细胞中topoisomerase II-α催化的ATP水解50%。 | |||
T83680 |
Azurin (50-77) (P. aeruginosa) TFA
Azurin p28,p28 |
||
Azurin (50-77)是一种含铜细菌蛋白azurin的肽段,存在于P. aeruginosa中,具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂(IC20约为10.7 µM),Azurin (50-77)(20 µM)能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下,减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成(IC50 = 12 µM),降低人脐静脉内皮细胞(HUVECs)中与细胞膜相关的F-actin、焦点粘附激酶(FAK)和paxillin的水平,并增加胞外的血小板内皮细胞粘附分子-1(PECAM-1)的水平。在体内,Azurin (50-77)(每日10 mg/kg)在MCF-7小鼠异种移植模型中减少肿瘤体积。 | |||
T35683 |
2-deoxy-D-Glucose-13C6
2-deoxy-D-Glucose-13C6 |
||
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste... |