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Search Results for " antibacterial compound 2 "

32

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11427	Antibacterial compound 2	Antifungal	Microbiology/Virology
	Antibacterial compound 2 是一种有效的抗菌剂，对许多人类兽医病原体有效，对多重耐药葡萄球菌、肠球菌和链球菌，以及厌氧菌有抑制作用。
T17254	Amifloxacin Win49375,氨氟沙星	Antibacterial	Microbiology/Virology
	Amifloxacin (Win49375) 是有效的喹诺酮类抗菌剂。
T50068	2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide	Others	Others
	2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide 是一种用作分子结构单元的化合物，为环状二肽。它可以诱导细胞凋亡、抑制细胞增殖和调节免疫反应，具有广泛的生物活性，包括抗肿瘤、抗真菌、抗细菌、抗病毒和免疫条件活性等。
T62734	SARS-CoV-2 3CLpro-IN-4
	SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a multifunctional inhibitor of SARS CoV-2 3CLpro, exhibiting antiviral, antibacterial, and antifungal activities.
T64197	Antibacterial agent 112
	Antibacterial agent 112 (compound 2) 是一种有效的抗菌剂 (antibacterial)。Antibacterial agent 112 对 P.aeruginosa (MIC: 625 μM)、S.mutans (MIC: 625 μM)、B.subtilis (MIC: 1250 μM)、E.coli (MIC: 1250 μM)、E.faecalis (MIC: 1250 μM)、S.typhimuriumand (MIC: 1250 μM) 和 S.aureus microorganisms (MIC: 1250 μM)具有抗菌活性。
T74622	Antibacterial agent 109
	Antibacterial agent 109 (Compound C-2) 是一种有效的抗细菌 (antibacterial) 剂，对革兰氏阳性和革兰氏阴性细菌均有效，且无诱变作用。Antibacterial agent 109 通过阻断新肽链的延伸抑制蛋白质合成。
T74966	Antimicrobial agent-10
	Antimicrobial agent-10 是一种 SARS-CoV-2 抑制剂，具有良好的抗菌活性。
T62389	14α-Demethylase/DNA Gyrase-IN-2
	14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T74968	Antimicrobial agent-12
	Antimicrobial agent-12 是一种有效的抗菌剂，同时具有 SARS-CoV-2 抑制活性。
T61948	MraY-IN-2
	MraY-IN-2 (compound 6) 是有效的细菌转位酶MraY 抑制剂（IC50=4.5 μM），可用于抗菌研究。
T61780	MtTMPK-IN-4
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory activity against tyrosinase. Furthermore, MtTMPK-IN-4 exhibits potent antibacterial properties [1] [2].
T14359	AVX 13616	Others	Others
	AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin i
T16565	Ppc-1	Others	Others
	Ppc-1 is a chemical compound known for its inhibitory effects on the Gram-negative periodontopathogen Porphyromonas gingivalis. It acts as a mitochondrial uncoupler, enhancing mitochondrial oxygen consumption without affecting ATP production. Additionally, Ppc-1 serves as a cell-permeate inhibitor of interleukin-2 (IL-2). This compound exhibits various beneficial activities, including anti-obesity, antibacterial, and anti-inflammatory properties.
T82944	ATP Synthesis-IN-2
	ATP Synthesis-IN-2 (Compound 5) 是一种有效的ATP合成活性抑制剂，对Pseudomonas aeruginosa (PA) 表现出抗菌活性，其IC50值为0.7 μg/mL。
T37470	Bismuth subcarbonate
	Bismuth subcarbonate, also known as bismuth carbonate oxide, is a versatile semiconductor compound based on bismuth, commonly utilized for its antibacterial properties, as well as in various applications such as sensors, super capacitors, and photocatalysts. Additionally, bismuth subcarbonate serves as a protective agent against gastric acid erosion, particularly in the treatment of gastric ulcers[1][2].
T60299	MurA-IN-2
	MurA-IN-2 (compound 37) 是一种含有伯胺的氯乙酰胺片段，它是一种有效的 MurA 抑制剂，其 IC50值为 39 μM。MurA-IN-2 具有抗菌活性，抑制细菌细胞壁合成。
T62486	VIM-2-IN-1
	VIM-2-IN-1 (compound 1dj) 是一种 β-内酰胺酶 (β-lactamase) 抑制剂，具有抗菌作用。VIM-2-IN-1 能够作用于 Verona 整合子编码的金属-β-内酰胺酶 (VIM-2) (IC50: 23 μM)、德国亚胺培内酶-1 (GIM-1) (IC50: 48 μM) 和新德里金属 (NDM-1) (IC50: 231 μM)。
T13149	Thiocillin I	Antibacterial	Microbiology/Virology
	Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains(MIC of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively).
T81911	LtaS-IN-2
	LtaS-IN-2 (compound 13) 作为LTA synthesis的抑制剂，对Staphylococcus aureus和Staphylococcus epidermidis表现出有效的抗菌活性，其MIC90 值分别为0.5 μg/mL和1 μg/mL。该化合物是LtaS-IN-1的派生化学物。
T83096	Antibiofilm agent-2
	Antibiofilm agent-2（化合物 4T）是一种具有3.6 μM IC50的高效生物膜抑制剂。作为针对铜绿假单胞菌的抗菌增效剂，它能够抑制群体感应系统和铁稳态。
T82342	Gamma-Glutamyl Transferase-IN-2
	Gamma-Glutamyl Transferase-IN-2 (compound 4dq)，一种β-羰基酰肼类抑制剂，针对谷氨酰转移酶 (gamma-glutamyl transferase)，展现其抗真菌与抗菌活性。该化合物通过诱导活性氧积累、破坏细胞膜以及干扰组蛋白乙酰化来发挥其生物学效应。
T78866	DNA Gyrase-IN-9	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DNA Gyrase-IN-9 (compound 4j) 是一款抗细菌剂，作用于 DNA gyrase。该化合物对抑制革兰氏阳性菌的最小抑菌浓度（MIC）范围为 0.5-2 μg/mL，最小杀菌浓度（MBC）为 2-8 μg/mL。在金黄色葡萄球菌中，DNA Gyrase-IN-9 的 DNA gyrase 抑制半数有效浓度（IC50）为 6.29 μg/mL。
T61498	Sulfisoxazole diethanolamine
	Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothelin receptor A with an IC50 value of 0.60 μM and endothelin receptor B with an IC50 value of 22 μM. Additionally, Sulfisoxazole diethanolamine has been found to inhibit the release of breast cancer exosomes by specifically targeting endothelin receptor A [1] [2].
T72154	Topoisomerase IV inhibitor 2	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseIV inhibitor 2 (compound 5d) 是一种 DNA 拓扑异构酶 IV 抑制剂，其对 TOPO IV 和 DNA 促旋酶的 IC50 值分别为 0.35 μM 和 0.55 μM。此化合物显示出针对 Staphylococcus aureus Newman 菌株和 Escherichia coli ATCC8739 的抗菌活性，对应的 MIC 值分别为 1.985 μM 和 0.744 μM。
T80139	CRAMP-18 (mouse)	Antibiotic	Microbiology/Virology
	CRAMP-18 (mouse)为一种抗生素肽，具备抗革兰氏阴性菌能力而不具溶血活性，能有效抑制包括S. typhimurium和P. aeruginosa在内的菌株。此外，CRAMP-18 (mouse)展现了抗真菌、抗细菌及抗肿瘤的研究潜力。
T60914	Metallo-β-lactamase-IN-8
	Metallo-β-lactamase-IN-8 (化合物 17) 是有效，可逆和竞争性的广谱金属-β-内酰胺酶 (MβLs)抑制剂，具有抗菌活性。Metallo-β-lactamase-IN-8 对L1，ImiS，IMP-1和VIM-2的IC50值分别为 1.3 μM，5.7 μM，9.8 μM。
T75287	Sitafloxacin monohydrate
	Sitafloxacin monohydrate (DU6859a) 是一种具有广谱的抗菌活性，并对多种革兰氏阳性和革兰氏阴性细菌（包括厌氧菌）以及非典型病原体有效的口服活性氟喹诺酮类抗生素。它主要用于研究呼吸道感染和尿路感染。
T72153	Topoisomerase IV inhibitor 1	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseIV inhibitor 2 (compound 7d) 作为DNA拓扑异构酶IV（TOPO IV）抑制剂，展现出高效的活性，其对TOPO IV的IC50值为0.23 μM，而对DNA促旋酶的IC50为0.43 μM。此外，该化合物在抗菌领域同样表现出较强的能力，对金黄色葡萄球菌Nerman菌株（Staphylococcus aureus Newman）和大肠杆菌ATCC8739的最小抑菌浓度（MIC）分别为0.972 μM和0.608 μM。
T79240	DNA gyrase B-IN-2
	DNA gyrase B-IN-2 (Compound E) 是一款基于2-aminobenzothiazole的DNA gyrase B抑制剂，针对ESKAPE病原体显示出强效活性。该化合物在低纳摩尔浓度下表现出优异的DNA gyrase B抑制能力(IC50< 10 nM)，具备对多种ESKAPE病原体的广谱抗菌作用。对于大部分革兰氏阳性菌，最低抑菌浓度(MIC)低于0.03 μg/mL；针对革兰氏阴性病原体如E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa和Klebsiella pneumoniae，MIC为4 - 16 μg/mL。此化合物适用于感染性疾病的研究应用。
T61489	VEGFR-2/DHFR-IN-1
	VEGFR-2/DHFR-IN-1 (compound 8b) 是 VEGFR-2和DHFR 的抑制剂，其IC50值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌，粪链球菌，肠沙门氏菌，金黄色酿脓葡萄球菌，MSSA 和MRSA 显示了良好的抗菌活性，MIC 值分别为 16，16，16，8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26，HepG2 和 CF7 癌细胞系具有良好的细胞毒性，IC50值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。
T75509	Pulcherriminic acid
	Pulcherriminic acid 是环状二肽抗菌剂，对Fe3+有高亲和力，主要在芽孢杆菌和酵母中发现。该化合物通过非酶促反应与铁离子螯合，生成细胞外红色素pulcherrimin，通过竞争铁营养达到抗菌效果。Pulcherriminic acid 在食品、农业和医疗等领域具有广泛应用潜力。
T75281	Cephalexin hydrochloride monohydrate
	Cephalexin (Cefalexin) hydrochloride monohydrate 是一种口服有效的半合成头孢菌素类抗生素（antibiotic），对广泛的革兰氏阳性及革兰氏阴性细菌展现出抗菌活性。该化合物通过靶向青霉素结合蛋白（PBPs）抑制细菌细胞壁的组装，应用于包括肺炎、链球菌性咽喉炎、细菌性心内膜炎在内的疾病研究。

化合物

Antibacterial compound 2

Cat.No: T11427

Target: Antifungal

Cat.No: T17254

Synonym: Win49375,氨氟沙星

Target: Antibacterial

2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide

Cat.No: T50068

Target: Others

SARS-CoV-2 3CLpro-IN-4

Cat.No: T62734

Antibacterial agent 112

Cat.No: T64197

Antibacterial agent 109

Cat.No: T74622

Antimicrobial agent-10

Cat.No: T74966

14α-Demethylase/DNA Gyrase-IN-2

Cat.No: T62389

Antimicrobial agent-12

Cat.No: T74968

Cat.No: T61948

Cat.No: T61780

Cat.No: T14359

Target: Others

Cat.No: T16565

Target: Others

ATP Synthesis-IN-2

Cat.No: T82944

Bismuth subcarbonate

Cat.No: T37470

Cat.No: T60299

Cat.No: T62486

Cat.No: T13149

Target: Antibacterial

Cat.No: T81911

Antibiofilm agent-2

Cat.No: T83096

Gamma-Glutamyl Transferase-IN-2

Cat.No: T82342

DNA Gyrase-IN-9

Cat.No: T78866

Target: DNA/RNA Synthesis

Sulfisoxazole diethanolamine

Cat.No: T61498

Topoisomerase IV inhibitor 2

Cat.No: T72154

Target: Topoisomerase

CRAMP-18 (mouse)

Cat.No: T80139

Target: Antibiotic

Metallo-β-lactamase-IN-8

Cat.No: T60914

Sitafloxacin monohydrate

Cat.No: T75287

Topoisomerase IV inhibitor 1

Cat.No: T72153

Target: Topoisomerase

DNA gyrase B-IN-2

Cat.No: T79240

VEGFR-2/DHFR-IN-1

Cat.No: T61489

Pulcherriminic acid

Cat.No: T75509

Cephalexin hydrochloride monohydrate

Cat.No: T75281

Cat. No.	Product Name	Target	Signaling Pathways
T4406	2,6-Dimethylbenzoquinone m-Xyloquinone,2,6-二甲基苯醌,2,6-Dimethylquinone	Others	Others
	2,6-Dimethylbenzoquinone (2,6-Dimethylquinone) 是一种苯醌，一种存在于呕吐萝芙木和 Tibouchina pulchra 中的化合物。在生理浓度下 2, 6-Dimethoxy-p-benzoquinone 是一种抗菌物质。
T4S1452	Artemisic acid (+)-Artemisinic Acid,青蒿酸,Artemisinic acid	Antibacterial	Microbiology/Virology
	Artemisic acid ((+)-Artemisinic Acid) 是黄花蒿中分离得到的一种倍半萜，具有多种药理活性，如抗疟、抗菌和抗肿瘤活性，以及解热、化感和抗脂肪生成作用。
T72235	Antibacterial synergist 2
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
T75610	lsocryptomerin
	lsocryptomerin 是一种具有膜活性的抗真菌 (antifungal) 化合物，可从 Selaginella tamariscina 中分离得到。lsocryptomerin 能使真菌质膜去极化。lsocryptomerin 还具有抗癌和抗细菌 (antibacterial) 活性。
T75577	3′-Omethyl-5′-hydroxydiplacone
	3′-Omethyl-5′-hydroxydiplacone（化合物 2）为C-6-香叶基黄酮类化合物，从毛泡桐果实乙醇提取物中分离出。此化合物对革兰氏阳性菌展现出抗菌活性。
T75507	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone
	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone 对幽门螺杆菌菌株 51 表现出有效的抗菌活性，MIC50 值和 MIC90 值分别为 22 µM 和 50 µM。该化合物展现了在研究胃及十二指肠溃疡方面的潜力。
T35532	Galegine hydrochloride
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...
T75665	3-O-Methylellagic acid
	3-O-Methylellagic acid 是一种天然产物，从Myrciaria cauliflora 中分离得到，具有抗炎活性。3-O-Methylellagic acid 对葡萄糖转运有抑制作用。3-O-Methylellagic acid 具有抗菌活性，对葡萄球菌 ATCC 25923 菌株作用的 MIC 值为 32 μg/mL。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

2,6-Dimethylbenzoquinone

Cat.No: T4406

Synonym: m-Xyloquinone,2,6-二甲基苯醌,2,6-Dimethylquinone

Target: Others

Cat.No: T4S1452

Synonym: (+)-Artemisinic Acid,青蒿酸,Artemisinic acid

Target: Antibacterial

Antibacterial synergist 2

Cat.No: T72235

Cat.No: T75610

3′-Omethyl-5′-hydroxydiplacone

Cat.No: T75577

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone

Cat.No: T75507

Galegine hydrochloride

Cat.No: T35532

3-O-Methylellagic acid

Cat.No: T75665

Cat.No: T35624

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