Cat. No. | Product Name | Target | Signaling Pathways |
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T60560 |
Anti-inflammatory agent 15
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Anti-inflammatory agent 15 (化合物 29) 是有效的抗结核分枝杆菌剂,可用于结核病(TB)的研究。Anti-inflammatory agent 15 抑制 Mtb H37Rv 和 M299生长,MIC50分别为 2.3 和 7.8 μM。Anti-inflammatory agent 15也是一种抗炎剂, 通过抑制 iNOS 的表达来抑制 NO,同时也抑制 TNF-α 和 IL-1β 的产生。 | |||
T35708 | N-acetyl-5-Aminosalicylic Acid | ||
N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by ... | |||
T78855 |
Anticancer agent 157
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NO Synthase | Immunology/Inflammation |
Anticanceragent 157(compound 15)是一种NO抑制剂,具有抗炎和抗癌特性,IC50值为0.62 μg/mL。它能够与iNOS和caspase 8结合,进而导致核断裂和染色质浓缩,从而诱导细胞凋亡。此外,Anticanceragent 157在不同癌细胞系中展现出显著的抑制活性,对HT29结肠癌细胞的IC50为2.45 μg/mL,对Hep-G2肝癌细胞的IC50为3.25 μg/mL,以及对B16-F10鼠黑色素瘤细胞的IC50为3.84 μg/mL。 |