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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T83667 A11 TFA

CPP-EYVQTVKSSKG

A11是一种细胞穿透肽,由HIV-1 Tat蛋白质转导域与对应于脂联素A1 N末端第20至30残基的11氨基酸肽连接而成。它减少脂联素A1与Eph受体酪氨酸激酶A2(EphA2)的结合,并在HK1鼻咽癌(NPC)细胞中增加EphA2的泛素化。A11(10 µM)抑制HK1和5-8F NPC细胞的增殖、迁移和侵袭。在体内,A11减少5-8F和HK1 NPC小鼠异种移植模型中的肿瘤体积。
T83727 Tat-NTS Peptide TFA

Tat-Nuclear Translocation Signal Peptide

Tat-NTS肽是一种能穿透细胞的肽,由HIV-1 Tat蛋白的转导域与对应于脂联素A1重复III域残基228-237的10个氨基酸肽链接而成,扮演核转运信号(NTS)的角色。它通过阻断脂联素A1与进口素β之间的蛋白质-蛋白质相互作用,阻止脂联素A1在初级鼠海马神经元中的核内转运。Tat-NTS抑制初级鼠海马神经元在葡萄糖-氧剥夺及再灌注诱导的细胞凋亡。在体内,Tat-NTS(10 mg/kg)有效减少了由中脑动脉闭塞(MCAO)引起的缺血-再灌注损伤模型小鼠的梗塞体积和神经元凋亡,并缩短了在Morris水迷宫测试中达到平台的时间。
T36978 AS-99 TFA

AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1]. AS-99 TFA is tested against a panel of 20 histone methyltransferases, including NSD1, NSD2, NSD3, and SETD2. NO significant inhibition is observed at 50 μM of AS-99 TFA on any of the tested...

化合物

A11 TFA
Cat.No: T83667
Synonym: CPP-EYVQTVKSSKG
Target:
Tat-NTS Peptide TFA
Cat.No: T83727
Synonym: Tat-Nuclear Translocation Signal Peptide
Target:
AS-99 TFA
Cat.No: T36978
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-01381 ANXA10 Protein, Human, Recombinant

Annexin-10,ANX14,Annexin-14,ANXA<...

Human E. coli
Annexin A10 (ANXA10) contains four Annexin repeats and is a member of the Annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is reported that ANXA10 may be a clinical relevant marker for predicting outcome in both early and advanced stages of bladder cancer.
TMPY-01751 DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor necrosis factor re...

Human HEK293 Cells
DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-05760 DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

TRAMP,tumor necrosis factor receptor superfamily, member 25,...

Human HEK293 Cells
DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-00961 ADAM15 Protein, Human, Recombinant (His)

MDC15,ADAM metallopeptidase domain 15

Human HEK293 Cells
ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.
TMPY-02300 BIN1 Protein, Human, Recombinant (His)

AMPHL,bridging integrator 1,AMPH2,SH3P9

Human E. coli
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...

重组蛋白

ANXA10 Protein, Human, Recombinant
Cat.No: TMPJ-01381
Species: Human
Expression System: E. coli
DR3/TNFRSF25 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-01751
Species: Human
Expression System: HEK293 Cells
DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05760
Species: Human
Expression System: HEK293 Cells
ADAM15 Protein, Human, Recombinant (His)
Cat.No: TMPY-00961
Species: Human
Expression System: HEK293 Cells
BIN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02300
Species: Human
Expression System: E. coli
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