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14

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31148	Cyloone American cyanamid AC 43,064,ENT 25,809,American cyanamid CL-43064,BRN 4804631
	Cyloone is a bio-active chemical. Detailed information has not been published.
T31641	ENT 25641 AC 28,865 AI3-25641,Benzenesulfonamide, p-hydroxy-, dimethyl phosphate,American cyanamid CL-28865,ENT25641,ENT-25641
	ENT 25641 is a bio-active chemical. Detailed information has not been published.
T68845	Americanin A
	Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.
T25156	BiPNQ
	BiPNQ is a Trypanosoma cruzi inhibitor. Trypanosoma cruzi is the etiological agent of Chagas disease (American trypanosomiasis).
TP2447	Angiotensin I, asn(1)-val(5)-gly(9)-
	Angiotensin I, asn(1)-val(5)-gly(9)- is isolated from the plasma of American eel, Anquilla rostrata.
T82581	Dermaseptin-B4
	Dermaseptin-B4为来源于南美洲树蛙Phyllomedusa bicolor皮肤分泌物的一种抗菌肽。
T82580	Dermaseptin-B5
	Dermaseptin-B5是源自南美洲Phyllomedusa bicolor蛙类皮肤分泌物的抗菌肽。
T76656	Pseudin-2
	Pseudin-2 是可从南美奇异多指节蟾皮肤中分离出来的 AMP，对革兰氏阴性菌有较强的生长抑制作用。
T40100	D-Luciferin 6′-methyl ether 6′-Methoxyluciferin,D-Luciferin 6′-methyl ether
	D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (referred to as PpyLuc). It exhibits an IC50 value of 0.1 μM. This compound, which is an analog of D-luciferin, interacts non-specifically with the ATP and luciferin binding sites within the active site of PpyLuc.
T32849	Loline
	Loline is a natural insecticidal and deterrent to a broad range of insects, including species in the Hemiptera, Coleoptera, Hymenoptera, Lepidoptera, and Blattodea orders. Loline deters species such as the bird cherry-oat aphid (genus Rhopalosiphum), larg
T83529	(Rac)-Luciferin 6′-methyl ether sodium (Rac)-6′-Methoxyluciferin sodium
	D-Luciferin 6'-methyl ether (6'-Methoxyluciferin; compound 19a) sodium 是北美萤火虫Photinus pyralis荧光素酶 (PpyLuc) 的有效抑制剂，具有0.1 μM的IC50值。作为D-荧光素的类似物，本化合物在PpyLuc的ATP及荧光素结合位点展示了非特异性的相互作用。
T35507	12-HETE
	(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers . It aggregates neutrophils with an EC50 value of 40 nM.[1] Reference：[1]. O'Flaherty, J.T., Thomas, M.J., Lees, C.J., et al. Neutrophil-aggregating activity of monohydroxyeicosatetraenoic acids. American Journal of Pathology 104, 55-62 (1981).
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...
T35890	Pentosidine
	Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of ...

化合物

Cat.No: T31148

Synonym: American cyanamid AC 43,064,ENT 25,809,American cyanamid CL-43064,BRN 4804631

Cat.No: T31641

Synonym: AC 28,865 AI3-25641,Benzenesulfonamide, p-hydroxy-, dimethyl phosphate,American cyanamid CL-28865,ENT25641,ENT-25641

Cat.No: T68845

Cat.No: T25156

Angiotensin I, asn(1)-val(5)-gly(9)-

Cat.No: TP2447

Cat.No: T82581

Cat.No: T82580

Cat.No: T76656

D-Luciferin 6′-methyl ether

Cat.No: T40100

Synonym: 6′-Methoxyluciferin,D-Luciferin 6′-methyl ether

Cat.No: T32849

(Rac)-Luciferin 6′-methyl ether sodium

Cat.No: T83529

Synonym: (Rac)-6′-Methoxyluciferin sodium

Cat.No: T35507

Tucatinib hemiethanolate

Cat.No: T36648

Cat.No: T35890

Cat. No.	Product Name	Target	Signaling Pathways
TN7041	(-)-Epipodophyllotoxin	Apoptosis	Apoptosis
	(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂，在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。
T29963	Americanol A
	Americanol A enhances choline acetyltransferase activity; has neurotrophic properties.
T5547	Furaneol 呋喃酮,4-Hydroxy-2,5-dimethyl-3(2H)furanone,HDMF	Antibacterial	Microbiology/Virology
	Furaneol (HDMF) 主要来源于美洲葡萄（Vitis labrusca）及其杂交品种。作为水果中的重要香气成分，在一些葡萄酒中展现出类似草莓的香气特征。
T3920	Pseudoginsenoside F11 Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11	Others; Endogenous Metabolite	Metabolism; Others
	Pseudoginsenoside F11 (Ginsenoside A1) 从人参根和叶中分离得到。PF11在一系列心血管和中枢神经系统疾病中具有广泛的保护作用。
T29794	Akagerine
	Akagerine is derived from the root bark of South American Strychnos.
T82558	Dihydrobaicalin
	Dihydrobaicalin，一种从黄芩(Scutellaria lateriflora L.) 中分离出的黄酮苷。

天然产物

(-)-Epipodophyllotoxin

Cat.No: TN7041

Target: Apoptosis

Cat.No: T29963

Cat.No: T5547

Synonym: 呋喃酮,4-Hydroxy-2,5-dimethyl-3(2H)furanone,HDMF

Target: Antibacterial

Pseudoginsenoside F11

Cat.No: T3920

Synonym: Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11

Target: Others, Endogenous Metabolite

Cat.No: T29794

Dihydrobaicalin

Cat.No: T82558

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