Cat. No. | Product Name | Target | Signaling Pathways |
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T1242 |
Alvimopan
爱维莫潘 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂,IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中,可用于术后肠梗阻的研究。 | |||
T1242L |
Alvimopan monohydrate
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Alvimopan monohydrate is a mu-opioid receptor antagonist that intended for the treatment of constipation in patients who take opiates for pain. | |||
T22238 | Alvimopan dihydrate (LY246736 dihydrate) | ||
Alvimopan dihydrate(ADL 8-2698 dihydrate)是一种有效的μ-阿片受体(μ-opioid receptor)可逆拮抗剂,具备口服活性,选择性强,IC50值为1.7 nM。其对μ-阿片受体的选择性(Ki=0.47 nM)远高于κ-(Ki=100 nM)和δ-阿片受体(Ki=12 nM),显示出在术后肠梗阻研究中的潜力。 | |||
T20081 |
ADL-08-0011
ADL 08-0011 |
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ADL-08-0011 is an metabolite of alvimopan. | |||
T70267 |
ADL 08-0011 HCl
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ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverse... |