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Search Results for " acridone "

11

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T60331	Acridone-4-carboxylic acid
	Acridone-4-carboxylic acid (ACA) (Compound 2c) 是一种 acridone 衍生物，可与血红素相互作用，阻断游离血红素介导的蛋白质氧化和降解。Acridone-4-carboxylic acid 抑制蛋白质羰基形成，IC50为 43 μM。
T60280	3,6-Diamino-9(10H)-acridone
	3,6-Diamino-9(10H)-acridone 是拓扑异构酶的抑制剂。
T18882	2-Aminoacridone	Others	Others
	2-Aminoacridone 是一种荧光团 (λexc= 428nm, λem= 525nm)，普遍用于标记不饱和二糖。
T131490	1,3-Dihydroxy-10-methylacridone
	1,3-Dihydroxy-10-methylacridone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131490。
T8321	10-methyl-9-(phenoxycarbonyl) Acridinium	Others	Others
	10-methyl-9-(phenoxycarbonyl) Acridinium 是一种吖啶鎓酯，在碱性条件下与过氧化氢、过硫酸盐和其他氧化剂氧化后会产生荧光 10-methyl-9-acridone。
T30189	Atalaphillinine
	Atalaphillinine is an acridone alkaloid.
T78641	ER-27319	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	ER-27319为吖啶酮衍生物，高效选择性抑制SYK，阻断其酪氨酸磷酸化和活性。本化合物阻止抗原刺激下人及大鼠肥大细胞释放过敏介质，IC50约为10 μM，适用于过敏性疾病研究。
T61283	Topoisomerase II inhibitor 3
	Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].
T35484	5,7,8-Trimethoxydictamnine
	5,7,8-Trimethoxydictamnine is a quinoline alkaloid that has been found inRutaceaeand has antimalarial activity.1It is active against chloroquine-sensitive and -resistant strains ofP. falciparum(IC50s =19.9 and 5.72 μg/ml, respectively). 1.Basco, L.K.M., S., Skaltsounis, A.-L., Ravvelomanantsoa, N., et al.In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparumAntimicrob. Agents Chemother.38(5)1169-1171(1994)
T38159	STING Agonist 12b
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T35739	Evoxanthine
	Evoxanthine is an alkaloid that has been found in O. renieri and has antimalarial and anticancer activities.1,2 It is active against P. falciparum with an IC50 value of 67.6 μg/ml.1 Evoxanthine decreases proliferation of nine sensitive and drug-resistant cancer cell lines (IC50s = 6.11-80.99 μM).2 \|1. Khalid, S.A., Farouk, A., Geary, T.G., et al. Potential antimalarial candidates from African plants: And in vitro approach using Plasmodium falciparum. J. Ethnopharmacol. 15(2), 201-209 (1986).\|2. ...

化合物

Acridone-4-carboxylic acid

Cat.No: T60331

3,6-Diamino-9(10H)-acridone

Cat.No: T60280

2-Aminoacridone

Cat.No: T18882

Target: Others

1,3-Dihydroxy-10-methylacridone

Cat.No: T131490

10-methyl-9-(phenoxycarbonyl) Acridinium

Cat.No: T8321

Target: Others

Atalaphillinine

Cat.No: T30189

Cat.No: T78641

Target: Syk

Topoisomerase II inhibitor 3

Cat.No: T61283

5,7,8-Trimethoxydictamnine

Cat.No: T35484

STING Agonist 12b

Cat.No: T38159

Cat.No: T35739

Cat. No.	Product Name	Target	Signaling Pathways
T20003	Acridone	Antibacterial; ABC	Membrane transporter/Ion channel; Microbiology/Virology
	Acridone 具有抗菌、抗疟、抗病毒和抗肿瘤活性。它可诱导细胞凋亡，抑制 ABCG2 蛋白，并调节激素水平。
TN4928	Rutacridone	P450	Metabolism
	Rutacridone has mutagenicity.
TN6171	1,3-Dihydroxy-2,4-diprenylacridone
	1,3-Dihydroxy-2,4-diprenylacridone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6171，CAS号为 1205687-48-4。
TN2538	1-Hydroxy-N-methylacridone	Others	Others
	1-Hydroxy-N-methylacridone is a natural product from Ruta chalepensis.
TN2520	1,7-Dihydroxyacridone	Others	Others
	1,7-Dihydroxyacridone is a natural product from Boenninghausenia albiflora.
TN6066	1-Hydroxyacridone
	1-Hydroxyacridone has potential antiviral activity.

天然产物

Cat.No: T20003

Target: Antibacterial, ABC

Cat.No: TN4928

Target: P450

1,3-Dihydroxy-2,4-diprenylacridone

Cat.No: TN6171

1-Hydroxy-N-methylacridone

Cat.No: TN2538

Target: Others

1,7-Dihydroxyacridone

Cat.No: TN2520

Target: Others

1-Hydroxyacridone

Cat.No: TN6066

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