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Search Results for " atpases "

14

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14965	Ciliobrevin D	ATPase; Hedgehog/Smoothened	GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Ciliobrevin D 是细胞渗透性，可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。
T9882	RUVBL1/2 ATPase-IN-1	Others	Others
	RUVBL1/2 ATPase-IN-1 是一种有效的 RUVBL1/2 ATPase 抑制剂，IC50 值分别为 6.0 和 7.7 μM。 RUVBL1/2 ATPase-IN-1 可用于癌症疾病的研究。
T2686L	Esomeprazole Sodium 埃索美拉唑钠,(S)-Omeprazole sodium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T2686	Esomeprazole Magnesium (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T8386	Esomeprazole Magnesium trihydrate 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate	Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T17030	Tegoprazan	ATPase; Proton pump	Membrane transporter/Ion channel
	Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，能够控制胃酸分泌和运动，在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。
T21550	Blebbistatin (±)-Blebbistatin	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Blebbistatin ((±)-Blebbistatin) 是一种选择性的非肌肉肌球蛋白 II 抑制剂，可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合，并保留了细胞连接的完整性和屏障功能。
T6038	(-)-Blebbistatin (S)-(-)-Blebbistatin	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	(-)-Blebbistatin ((S)-(-)-Blebbistatin) 是 blebbistatin 的 S 对映异构体。它是一种有效的选择性肌球蛋白 II 抑制剂，IC50 范围为 0.5 至 5 μM。
T36116	Concanamycin B
	Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell su...
T28626	Rutamycin Oligomycin D,A272,A 272,A-272
	Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport.
T76374	SPAI-1
	SPAI-1，特异性单价阳离子ATP酶抑制剂，源自猪十二指肠。能体外抑制Na+，K+-ATP酶和H+，K+-ATP酶，同时刺激Mg2+-ATP酶。
T75585	Naja Mossambica Venom
	Naja Mossambica Venom (Mozambique Spitting Cobra Venom) 是一种蛇毒，可从 Naja Mossambica 获得。Naja Pallida Venom 对Candida 物种具有抗真菌活性。Naja Mossambica Venom 提取物 (如磷脂酶 A2) 可抑制钠钾 ATP 酶活性。
T36335	(S)-nitro-Blebbistatin
	(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. H...
T36400	para-amino-Blebbistatin
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...

化合物

Cat.No: T14965

Target: ATPase, Hedgehog/Smoothened

RUVBL1/2 ATPase-IN-1

Cat.No: T9882

Target: Others

Esomeprazole Sodium

Cat.No: T2686L

Synonym: 埃索美拉唑钠,(S)-Omeprazole sodium

Target: ATPase, Proton pump

Esomeprazole Magnesium

Cat.No: T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Esomeprazole Magnesium trihydrate

Cat.No: T8386

Synonym: 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate

Target: Proton pump

Cat.No: T17030

Target: ATPase, Proton pump

Cat.No: T21550

Synonym: (±)-Blebbistatin

Target: ATPase, Myosin

(-)-Blebbistatin

Cat.No: T6038

Synonym: (S)-(-)-Blebbistatin

Target: ATPase, Myosin

Cat.No: T36116

Cat.No: T28626

Synonym: Oligomycin D,A272,A 272,A-272

Cat.No: T76374

Naja Mossambica Venom

Cat.No: T75585

(S)-nitro-Blebbistatin

Cat.No: T36335

para-amino-Blebbistatin

Cat.No: T36400

Cat. No.	Product Name	Target	Signaling Pathways
T4897	Inosine-5'-triphosphate trisodium salt ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt	Others; Endogenous Metabolite	Metabolism; Others
	Inosine-5'-triphosphate trisodium salt (ITP) 是三磷酸核苷，能够作为 ATPases 和 GTPases 的底物。
T22598	Bafilomycin C1 巴菲霉素C1	Others	Others
	vacuolar H+-ATPases (V-ATPases) inhibitor
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].

天然产物

Inosine-5'-triphosphate trisodium salt

Cat.No: T4897

Synonym: ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt

Target: Others, Endogenous Metabolite

Cat.No: T22598

Synonym: 巴菲霉素C1

Target: Others

Manzamine A hydrochloride

Cat.No: T38441

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