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Cat. No. Product Name Target Signaling Pathways
T14175 Aldose reductase-IN-1

AT-001,Caficrestat

Others; Reductase Endocrinology/Hormones; Metabolism; Others
Aldose reductase-IN-1 (AT-001)是醛糖还原酶的高效抑制剂, IC50=为28.9 pM。
T12711 Retro-2 cycl

RN 1-001

Virus Protease Microbiology/Virology
Retro-2 cycl 是一种抗病毒剂,是一种逆行运输抑制剂,抑制 JCPyV(IC50s:54 μM)和 HPV16 假病毒(IC50s:160 μM)。
T65994 (6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation...
T68332 AKI-001

AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Phenotypic cellular assays show that both Aurora A and Aurora B are inhibited at inhibitor concentrations sufficient to block proliferation. Importantly, the cellular activity translates to potent inhibition of tumor growth in vivo. An oral dose of 5 mg/kg QD is well tolerated and results in near s...

化合物

Aldose reductase-IN-1
Cat.No: T14175
Synonym: AT-001,Caficrestat
Target: Others, Reductase
Retro-2 cycl
Cat.No: T12711
Synonym: RN 1-001
Target: Virus Protease
(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Cat.No: T65994
Synonym:
Target:
AKI-001
Cat.No: T68332
Synonym:
Target:
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