Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14331 |
Gusacitinib
ASN-002 |
JAK; Syk | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Gusacitinib (ASN-002) 是一种有效的 SYK 激酶和JAK 激酶的双抑制剂,IC50值为 5 到 46 nM 之间,具有抗癌活性。 | |||
T69765 | NPD-039 | ||
NPD-039 is an inhibitor of trypanosoma brucei phosphodiesterase B1 (TbrPDEB1). | |||
T69766 | Gusacitinib HCl | ||
Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and... |