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Search Results for " ap-n "

Targets Recommended: NF-κB JNK

3

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3627	IQ-1S free acid IQ-1,IQ-1S,IQ-1S (free acid)	NF-κB; JNK	MAPK; NF-κB
	IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力。
T36943	Aminopeptidase N Inhibitor
	Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
T83856	AP-1
	AP-1是一种微型化的蛋白质水解靶向嵌合体（PROTAC），由吲哚美辛（±）连接的间变性淋巴瘤激酶（ALK）配体和E3泛素连接酶配体通过超短连接器相连。在10至300 nM浓度范围内使用时，AP-1能高效降解Karpas-299细胞中高表达的ALK融合蛋白NPM-ALK，此效应可被蛋白酶体抑制剂MG-132阻断。它还能降解在SN-N-SH和NCI H3122细胞中表达的ALK融合蛋白EML4-ALK及含有苯丙氨酸至亮氨酸替换突变（ALKF1174L）的ALK。AP-1对依赖ALK的Karpas-299细胞具有细胞毒性（IC50 = 0.1265 nM），但对非ALK依赖的THP-1细胞无细胞毒性（IC50 = 2,704 nM）。在给药剂量为25, 50, 和100 mg/kg时，能减小NCI H3122小鼠移植瘤模型中的肿瘤体积。

化合物

IQ-1S free acid

Cat.No: T3627

Synonym: IQ-1,IQ-1S,IQ-1S (free acid)

Target: NF-κB, JNK

Aminopeptidase N Inhibitor

Cat.No: T36943

Cat.No: T83856

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00758	Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His) Cd13,AP-N,Apn,AP	Mouse	HEK293 Cells
	Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104 kDa and the accession number is P97449.
TMPH-03099	Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) gp130,pAPN,AP-M,Aminopep...	Sus scrofa (Pig)	E. coli
	Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.1 kDa and the accession number is P15145.
TMPJ-00457	OGG1 Protein, Human, Recombinant OGH1,N-Glycosylase/DNA Lyase,DNA-...	Human	E. coli
	Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.

重组蛋白

Aminopeptidase N/CD13 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00758

Species: Mouse

Expression System: HEK293 Cells

Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc)

Cat.No: TMPH-03099

Species: Sus scrofa (Pig)

Expression System: E. coli

OGG1 Protein, Human, Recombinant

Cat.No: TMPJ-00457

Species: Human

Expression System: E. coli

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