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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T26834	BL-1020 Mesylate CYP-1020 Mesylate	Dopamine Receptor; GABA Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	BL-1020 Mesylate (CYP-1020 Mesylate) 是一种可口服的 GABA A 受体激动剂和 D2 拮抗剂，可降低多巴胺活性并增强GABAA活性。BL-1020 Mesylate 可用于研究神经分裂、阿尔茨海默症和双向认知障碍。
T28862	ST-168 ST168,ST 168
	ST-168 is a potent inhibitor of PI3K and MEK. ST-168 displays improved PI3K and MEK1 isoform inhibition. ST-168 demonstrated a 2.8-, 2.7-, 23-, and 2.5-fold improved inhibition toward the PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ isoforms and a 2.2-fold improvement
T62273	Vulolisib
	Vulolisib 是一种口服具有活力、有效的磷脂酰肌醇 3 激酶 (PI3K) 抑制剂，能够作用于 PI3Kα (IC50: 0.2 nM)、PI3Kβ (IC50: 168 nM)、PI3Kγ (IC50: 90 nM)、 PI3Kδ (IC50: 49 nM)。Vulolisib 具有抗肿瘤活性，对癌细胞表现出抗增殖活性。
T83082	Anticancer agent 168
	Anticanceragent 168（compound d16）是一种DNA2抑制剂。该化合物能够促进细胞凋亡（apoptosis），引起细胞周期在S期显著停滞，并在含mutp53肿瘤中显示出抗癌效应，有助于克服化疗耐药性。
T76872	Neihulizumab
	Neihulizumab (ALTB-168) 是一种免疫检查点激动性抗体，可与人 CD162 (PSGL-1)结合，导致活化的 T 细胞下调。Neihulizumab 可用于类固醇难治性急性移植物抗宿主病 (SR-aGVHD)、银屑病、银屑病关节炎和溃疡性结肠炎的研究。
T38020	O-Benzylhydroxylamine (hydrochloride)
	O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)19...
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela...

化合物

BL-1020 Mesylate

Cat.No: T26834

Synonym: CYP-1020 Mesylate

Target: Dopamine Receptor, GABA Receptor

ST-168

Cat.No: T28862

Synonym: ST168,ST 168

Anticancer agent 168

O-Benzylhydroxylamine (hydrochloride)

Cat.No: T38020

Synonym:

Target:

PMX-205 (trifluoroacetate salt)

Cat.No: T35836

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...