Cat. No. | Product Name | Target | Signaling Pathways |
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T30142 |
ARRY-403
AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151 |
Glucokinase | Metabolism |
ARRY-403 是一种新型葡萄糖激酶激活剂,可降低 2 型糖尿病患者的空腹和餐后血糖,可用于治疗糖尿病。 | |||
T70390 |
YM-543 choline
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YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose level... | |||
T70391 |
AMG151 HCl
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ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse... |