Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5854 |
AM580
NSC608001,CD336,Ro 40-6055 |
Retinoid Receptor; Autophagy | Autophagy; Metabolism |
AM580 (CD336) 是一种视黄酸受体激动剂,对 RARα 具有选择性,IC50和EC50分别为 8 和 0.36 nM。 | |||
T69615 |
AWD12-281 sodium
|
||
AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor for the treatment of lung inflammation using inhalative administration. AWD 12-281 Is Active in a New Guinea-Pig Model of Allergic Skin Inflammation Predictive of Human Skin Penetration and Suppresses Both Th1 and Th2 Cytokines in Mice. AWD 12-281 is a very promising drug candidate not only for the treatment of lung inflammation using inhalative administration but also for the treatment of atopic dermatitis. |