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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T79514 ABCG2-IN-2

BCRP Membrane transporter/Ion channel
ABCG2-IN-2为一有效ABCG2抑制剂,呈现小鼠良好口服药代动力学性质。适用于研究肿瘤多药耐药(MDR)与红细胞生成性原卟啉症(EPP)。
T36807 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)

Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 ...

化合物

ABCG2-IN-2
Cat.No: T79514
Synonym:
Target: BCRP
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
Cat.No: T36807
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T3S1775 Tectochrysin

NSC 80687,Techtochrysine,Techtochrysin,柚木柯因

NF-κB; STAT JAK/STAT signaling; NF-κB; Stem Cells
Tectochrysin (Techtochrysine) 是Alpinia oxyphylla 的主要黄酮类化合物之一,能够抑制NF-κB 活性。
TN7124 5-Hydroxy-2′,3,4′,7-tetramethoxyflavone

ABC Membrane transporter/Ion channel
5-Hydroxy-2',3,4',7-tetramethoxyflavone 显示出较弱的 ABCG2 抑制效力,在 Hoechst 33342 和脱镁叶绿素 A 测定中 IC50 分别为 3.27 和 3.89 µM。

天然产物

Tectochrysin
Cat.No: T3S1775
Synonym: NSC 80687,Techtochrysine,Techtochrysin,柚木柯因
Target: NF-κB, STAT
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
Cat.No: TN7124
Synonym:
Target: ABC
TargetMol Loading
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