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Cat. No. | Product Name | Target | Signaling Pathways |
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T79514 | ABCG2-IN-2 | BCRP | Membrane transporter/Ion channel |
ABCG2-IN-2为一有效ABCG2抑制剂,呈现小鼠良好口服药代动力学性质。适用于研究肿瘤多药耐药(MDR)与红细胞生成性原卟啉症(EPP)。 | |||
T36807 |
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
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Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3S1775 |
Tectochrysin
NSC 80687,Techtochrysine,Techtochrysin,柚木柯因 |
NF-κB; STAT | JAK/STAT signaling; NF-κB; Stem Cells |
Tectochrysin (Techtochrysine) 是Alpinia oxyphylla 的主要黄酮类化合物之一,能够抑制NF-κB 活性。 | |||
TN7124 |
5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
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ABC | Membrane transporter/Ion channel |
5-Hydroxy-2',3,4',7-tetramethoxyflavone 显示出较弱的 ABCG2 抑制效力,在 Hoechst 33342 和脱镁叶绿素 A 测定中 IC50 分别为 3.27 和 3.89 µM。 |