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Cat. No. | Product Name | Target | Signaling Pathways |
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T37000 |
7-Azido-4-methylcoumarin
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7-Azido-4-methylcoumarin (AzMC) is a coumarin fluorescent probe for hydrogen sulfide (H2S).1 AzMC selectively fluoresces in the presence of H2S over a panel of reactive nitrogen, oxygen, and sulfur species. AzMC displays excitation/emission maxima of 340/445 nm, respectively. |1. Chen, B., Li, W., Lv, C., et al. Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues. Analyst 138(3), 946-951 (2013). | |||
T4204 |
6-ethyl-7-hydroxy-4-methylchromen-2-one
6-ethyl-7-hydroxy-4-methylcoumarin |
Others | Others |
6-ethyl-7-hydroxy-4-methylchromen-2-one 是一种荧光染料 | |||
T18909 |
Ac-DEVD-AMC
AC-ASP-MET-GLN-ASP-AMC,AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN |
Caspase | Apoptosis; Proteases/Proteasome |
Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) 是一种 Caspase-3底物。 | |||
T7037 |
7-Acetoxy-4-methylcoumarin
7-乙酰氧基-4-甲基香豆素,MU-Ac |
Others | Others |
7-Acetoxy-4-methylcoumarin 是羧酸酯酶的荧光底物,在切割时会产生蓝色荧光溶液。该化合物已用于非质子介质(一种细胞膜环境模拟物),以研究分散在水介质中的模型生物膜的超氧化物和相关的氧自由基反应。由于 AchE 能够裂解和激活 7-Acetoxy-4-methylcoumarin,因此荧光底物已被用于研究 AchE 抑制剂 Tacrine·HCl (sc-200172)。该化合物也已从 Trigonella foenum graceum 中分离出来。 | |||
TD0075 |
7-Hydroxy-4-methylcoumarin-3-acetic acid
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7-Hydroxy-4-methylcoumarin-3-acetic acid is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. This coumarin is increasingly used to label peptides, nucleotides and carbohydrates. | |||
T37062 |
L-Leucine-7-amido-4-methylcoumarin hydrochloride
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L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O’Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometryS... | |||
T83256 |
7-(Dimethylamino)-4-methylcoumarin
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7-(Dimethylamino)-4-methylcoumarin,一种香豆素,主要用于香豆素荧光增白剂溶液研究。 | |||
T65237 | Glycine 7-amido-4-methylcoumarin hydrobromide | ||
Glycine 7-amido-4-methylcoumarin hydrobromide 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65237,CAS号为 113728-13-5。 | |||
TD0076 |
AMCA-H N-succinimidyl ester
7-Hydroxy-4-methylcoumarin-3-acetic acid, succinimidyl ester,7-羟基-4-甲基香豆素-3-乙酸琥珀酰亚胺酯 |
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The amine-reactive AMCA, SE (7-amino-4-methylcoumarin-3-acetic acid, succinimidyl ester) and its conjugates yield blue-fluorescence (approximate excitation/emission maxima ~353/442) that can be used as a contrasting color in multicolor applications. | |||
T36334 |
Z-VAD-AMC (acetate)
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Z-VAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | |||
T35932 |
Gly-Arg-AMC (hydrochloride)
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Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. |1. Rubach, J.K., Cui, G., Schneck, J.L., et al. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis. Biochemistry 51(38), 7551-7568 (2012). | |||
T37417 |
Z-LLE-AMC
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Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment. | |||
T36354 |
Suc-YVAD-AMC (acetate)
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Suc-YVAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | |||
T36341 |
Ac-DNLD-AMC
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Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. Upon enzymatic cleavage by caspase-3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-3 activity. AMC displays excitation/emission maxima of 340-360 and 440-460 nm, respectively. | |||
T36342 |
Ac-LEHD-AMC (trifluoroacetate salt)
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Ac-LEHD-AMC is a fluorogenic substrate for caspase-9.[1] Upon cleavage by caspase-9, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-9 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | |||
T37420 |
Ac-ANW-AMC
Ac-ANW-AMC,Ac-Ala-Asn-Trp-AMC |
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Ac-ANW-AMC is a fluorogenic substrate for the β5i/LMP7 subunit of the 20S immunoproteasome. [1] Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β5i/LMP7 subunit of the 20S immunoproteasome. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. Reference[1]. Winter, M.B., La Greca, F., Arastu-Kapur, S., et al. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. ... | |||
T37421 |
Ac-PAL-AMC
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Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm, respectively. | |||
T36346 |
Ac-VEID-AMC (ammonium acetate salt)
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Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. 1.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9... | |||
T37418 |
Z-LLL-AMC
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Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment. | |||
T36105 |
coumarin-SAHA
coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA |
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Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm | |||
T37053 |
Z-(L-Arg)-AMC (hydrochloride)
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Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrat... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7934 |
7-Methylcoumarin
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Others | Others |
7-Methylcoumarin 具有很强的保肝活性。 | |||
T8038 |
7-Ethoxy-4-Methylcoumarin
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Others | Others |
7-Ethoxy-4-Methylcoumarin 具有独特气味的芳香化合物。它被认为是细胞中酶的抑制剂,已被用于酶抑制的研究,并已被用于研究各种药物对人体的影响。 | |||
TJP2865 |
7-methoxy-8-hydroxy-4-methylcoumarin
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Others | Others |
7-methoxy-8-hydroxy-4-methylcoumarin 是分离自酸橙 (Citrus aurantium) 的一种化合物。 | |||
TN1328 |
7-Amino-4-methylcoumarin-3-acetic acid
7-氨基-4-甲基-3-香豆素醋酸,7-Amino-4-methylcoumarin |
Others | Others |
7-Amino-4-methylcoumarin-3-acetic acid (7-Amino-4-methylcoumarin) 是荧光蛋白质标记剂,能够被紫外光(350 nm) 激活,可在蓝色区域 (440-460 nm) 发光。 | |||
T2785 |
4-Methylherniarin
羟甲香豆素甲醚,7-Methoxy-4-methylcoumarin |
Others; Antibacterial | Microbiology/Virology; Others |
4-Methylherniarin (7-Methoxy-4-methylcoumarin) 可荧光标记,是香豆素衍生物,具有抗革兰氏阳性和革兰氏阴性细菌染色的活性。它对B. subtilis 和S.sonnei 有活性,IC50值为 11.76 μg/ml 和 13.47 μg/ml。 |