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Search Results for " 5trans latanoprost (free acid) "

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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37214	5-trans Latanoprost (free acid)
	Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. 5-trans Latanoprost (free acid) is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from ci...
T3627	IQ-1S free acid IQ-1,IQ-1S,IQ-1S (free acid)	NF-κB; JNK	MAPK; NF-κB
	IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力。
T37213	5-trans Latanoprost
	Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of between 2-5% in most commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. Fr...
T37933	15-keto Latanoprost (free acid)
	15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost is al...

化合物

5-trans Latanoprost (free acid)

Cat.No: T37214

IQ-1S free acid

Cat.No: T3627

Synonym: IQ-1,IQ-1S,IQ-1S (free acid)

Target: NF-κB, JNK

5-trans Latanoprost

Cat.No: T37213

15-keto Latanoprost (free acid)

Cat.No: T37933

Cat. No.	Product Name	Target	Signaling Pathways
T8504	Dianemycin Nanchangmycin (free acid)	Antibacterial; Antibiotic	Microbiology/Virology
	Dianemycin (Nanchangmycin (free acid)) 由Streptomyces nanchangensis 产生的一种聚醚抗生素，抑制革兰氏阳性菌。它也是一种针对 Zika 病毒的广谱抗病毒药物。

天然产物

Cat.No: T8504

Synonym: Nanchangmycin (free acid)

Target: Antibacterial, Antibiotic

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