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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T37571	4-Methylumbelliferyl-β-D-Glucopyranoside MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc,4-甲基伞形酮酰-Β-D-吡喃葡糖酸苷	Others	Others
	4-Methylumbelliferyl-β-D-Glucopyranoside (4-MU-GLU) 是β-glucosidase 的荧光底物，可用于β-glucosidase 活性的测定，期间释放出高荧光的 4-methylumbelliferyl (4-MU)，发射波长为 445-454 nm。4-MU 激发波长值与 pH 值有关，在 pH 值为 4.6、7.4 和 10.4 时分别为 330、370 和 385 nm。
T32788	LISA-4 H-Glu[Ser(CO-MU)]-OH,LISA 4
	LISA-4 is the first fluorescent dipeptide probe for γ-glutamyl cyclotransferase.
T7037	7-Acetoxy-4-methylcoumarin 7-乙酰氧基-4-甲基香豆素,MU-Ac	Others	Others
	7-Acetoxy-4-methylcoumarin 是羧酸酯酶的荧光底物，在切割时会产生蓝色荧光溶液。该化合物已用于非质子介质（一种细胞膜环境模拟物），以研究分散在水介质中的模型生物膜的超氧化物和相关的氧自由基反应。由于 AchE 能够裂解和激活 7-Acetoxy-4-methylcoumarin，因此荧光底物已被用于研究 AchE 抑制剂 Tacrine·HCl (sc-200172)。该化合物也已从 Trigonella foenum graceum 中分离出来。
T37191	Mu-6S-Palm-β-Glc
	Mu-6S-Palm-β-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mu-6S-Palm-β-Glc is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM...
T62768	Mu opioid receptor antagonist 4
	Mu opioid receptor antagonist 4 (compound 31) 是一种有效的、选择性的、能透过血脑屏障渗透性的μ 阿片受体 (MOR) 拮抗剂 (Ki: 0.38 nM, EC50: 0.38 nM)。Mu opioid receptor antagonist 2 对吗啡表现出明显的中枢神经系统拮抗活性，诱发戒断症状比 Naloxone 小。Mu opioid receptor antagonist 2 能够用于研究阿片类药物使用障碍 (OUD)。
T37192	4-Methylumbelliferyl-α-D-Galactopyranoside 4MU-α-Gal	Others	Others
	4-Methylumbelliferyl-α-D-Galactopyranoside (4MU-α-Gal) (4-MU-α-Gal)是α-半乳糖苷酶的荧光底物。除了用于表征新的α-半乳糖苷酶外，4-MU-α-Gal 还用于评估与法布里病相关的α-半乳糖糖苷酶活性的缺乏。
T1242	Alvimopan 爱维莫潘	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂，IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中，可用于术后肠梗阻的研究。
T37566	4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)
	4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio di...
T37568	4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)
	4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase defi...
T25147	beta-Casomorphin 4 Tyr-pro-phe-pro
	beta-Casomorphin 4 shows moderate analgesic activity for mu receptors.
T38119	4-Methylumbelliferyl Caprylate
	4-Methylumbelliferyl caprylate (MUCAP) is a fluorogenic substrate for C8 esterase. MUCAP is cleaved by C8 esterase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.
T36370	4-Methylumbelliferyl-α-L-Iduronide (free acid)
	4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an...
T37570	4-Methylumbelliferyl-β-D-N,N',N''-Triacetylchitotrioside
	4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases. 4-Methylumbelliferyl-β-D-N,N',N''-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. ...
T4411	DAMGO TFA (78123-71-4(Free base))	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DAMGO TFA (78123-71-4(Free base)) 是Mu-opioid 受体的强效选择性激动剂。它也是镇痛药。它刺激钙激活的腺苷酸环化酶相关 cAMP 的产生。通过 TGF-beta1 表达趋化因子和趋化因子受体。增加老鼠的食物摄入量。
T37569	4-Methylumbelliferyl-β-D-Galactoside
	4-Methylumbelliferyl-β-D-galactoside (MUG) is a fluorogenic substrate for β-galactosidase (β-gal).1Hydrolysis of MUG by β-gal releases the fluorescent moiety 4-MU, which displays a pH-dependent excitation maximum of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm.2MUG has been used to detect β-gal activity in intact bacteria, yeast, and mammalian cells.1 1.Vidal-Aroca, F., Giannattasio, M., Brunelli, E., et al.One-step high-throughput assay...
T37193	4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside
	4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-μU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbellife...
T37505	MCTR1 MCTR1
	Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflam...
T37506	MCTR2 MCTR2
	Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shor...
T37507	MCTR3 MCTR3
	Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase. MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1. Pretreatment with MCTR3 pri...
T36729	Urotensin II (goby) (trifluoroacetate salt)
	Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across ...
T36722	Deltorphin II (trifluoroacetate salt)
	Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid...

化合物

4-Methylumbelliferyl-β-D-Glucopyranoside

Cat.No: T37571

Synonym: MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc,4-甲基伞形酮酰-Β-D-吡喃葡糖酸苷

Target: Others

Cat.No: T32788

Synonym: H-Glu[Ser(CO-MU)]-OH,LISA 4

7-Acetoxy-4-methylcoumarin

Cat.No: T7037

Synonym: 7-乙酰氧基-4-甲基香豆素,MU-Ac

Target: Others

Mu-6S-Palm-β-Glc

Cat.No: T37191

Mu opioid receptor antagonist 4

Cat.No: T62768

4-Methylumbelliferyl-α-D-Galactopyranoside

Cat.No: T37192

Synonym: 4MU-α-Gal

Target: Others

Cat.No: T1242

Synonym: 爱维莫潘

Target: Opioid Receptor

4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt)

Cat.No: T37566

4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)

Cat.No: T37568

beta-Casomorphin 4

Cat.No: T25147

Synonym: Tyr-pro-phe-pro

4-Methylumbelliferyl Caprylate

Cat.No: T38119

4-Methylumbelliferyl-α-L-Iduronide (free acid)

Cat.No: T36370

4-Methylumbelliferyl-β-D-N,N',N''-Triacetylchitotrioside

Cat.No: T37570

DAMGO TFA (78123-71-4(Free base))

Cat.No: T4411

Target: Opioid Receptor

4-Methylumbelliferyl-β-D-Galactoside

Cat.No: T37569

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside

Cat.No: T37193

Cat.No: T37505

Synonym: MCTR1

Cat.No: T37506

Synonym: MCTR2

Cat.No: T37507

Synonym: MCTR3

Urotensin II (goby) (trifluoroacetate salt)

Cat.No: T36729

Deltorphin II (trifluoroacetate salt)

Cat.No: T36722

Cat. No.	Product Name	Target	Signaling Pathways
T1391	4-Methylumbelliferone Hymecromone,4-MU,胆通	Others	Others
	4-Methylumbelliferone (Hymecromone) 是透明质酸生物合成抑制剂，显示出抗肿瘤和抗转移活性。

天然产物

4-Methylumbelliferone

Cat.No: T1391

Synonym: Hymecromone,4-MU,胆通

Target: Others

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