Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40439 |
Sarizotan
EMD 128130 |
Others | Others |
Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors. It has shown potent activity with IC 50 values of 6.5 nM for rat 5-HT 1A , 0.1 nM for human 5-HT 1A , 15.1 nM for rat D 2 , 17 nM for human D 2 , 6.8 nM for human D 3 , and 2.4 nM for human D 4.2 . | |||
T70044 |
Sarizotan HCl
EMD 128130 HCl |
5-HT Receptor; HER | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors |
Sarizotan HCl (EMD 128130 HCl) 是一种 hERG 通道抑制剂和 5-羟色胺5-HT1A受体激动剂,具有潜在的抗抑郁作用,可用于研究帕金森运动障碍 |