Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15737 |
Lesogaberan
AZD-3355 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Lesogaberan is an effective and selective GABAB receptor agonist (EC50: 8.6 nM for human recombinant GABAB receptors). For rat brain GABAB and GABAA receptors, the binding affinity (Kis) is 5.1 nM and 1.4 μM, respectively. | |||
T68662 | AZD-3355 | ||
AZD-3355, also known as Lesogaberan, is a GABA(B)-receptor agonist reflux inhibitor. | |||
T72215 |
Lesogaberan hydrochloride
AZD-3355 hydrochloride |
||
Lesogaberan (AZD-3355) hydrochloride 是一种有效的选择性 GABAB 受体激动剂,对人重组 GABAB 受体的 EC50为 8.6 nM。通过脑膜中 [3H]GABA 结合位移测量,Lesogaberan hydrochloride 对大鼠 GABAB 和 GABAA 受体的亲和力 (Kis):分别为 5.1 nM 和 1.4 μM。Lesogaberan hydrochloride 通过外周作用模式抑制短暂的食管下括约肌松弛。 | |||
T40572 |
Lesogaberan napadisylate
AZD-3355 napadisylate |
||
Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 μM for GABA A receptors, as determined by its displacement of [3H]GABA binding in brain membranes. Notably, Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation. |