Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78582 |
15-keto-Prostaglandin E2
15-keto-PGE2 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
15-keto-Prostaglandin E2为内源性代谢产物,通过与STAT3Cys259残基结合,抑制STAT3激活作用。该化合物能够结合并稳定EP2与EP4受体,进而抑制乳腺癌细胞生长与进展,并通过激活PPAR-γ促进真菌生长。 | |||
T8763 |
PTGR2-IN-1
PTGR2-IN-22 |
Others | Others |
PTGR2-IN-1 是有效的 PTGR2抑制剂,IC50为 ~0.7 μM。它能够提高转染 PTGR2 的 HEK293T 细胞 15-keto-PGE2 依赖的 PPARγ 转录活性。 | |||
T67766 |
HHS-0701
|
Others | Others |
HHS-0701,一种硫-三唑交换 (SuTEx) 配体,是酪氨酸反应性前列腺素还原酶 2 (PTGR2) 的有效抑制剂。HHS-0701 可以抑制脂质底物 15-Keto-PGE2 的 PTGR2 代谢。 | |||
T36167 |
8-iso-15-keto Prostaglandin F2β
8-iso-15-keto Prostaglandin F2β |
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8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8... |