Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70646 |
Deltarasin HCl
|
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Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective" autophagy | |||
T6462 |
Deltarasin
|
PDE; Ras | GPCR/G Protein; MAPK; Metabolism |
Deltarasin 是一种 KRAS-PDEδ 相互作用的小分子抑制剂,与纯化的 PDEδ 结合,Kd 值为 38 nM。 |