Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70944 |
Carotegrast methyl HCl
|
Others | Others |
Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice. | |||
T30751 |
Carotegrast methyl
AJM300 |
Integrin | Cytoskeletal Signaling |
Carotegrast methyl (AJM300) 是一种口服有效和选择性 α4 整联蛋白拮抗剂,可预防小鼠结肠炎。HCA2969 是 Carotegrast methyl 的活性代谢产物,是一种特异的双重 α4β1/α4β7 整联蛋白拮抗剂。 |