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METAP1 Protein, Human, Recombinant (hFc)

产品编号 TMPY-00883

别名: MAP1A, MetAP1A, methionyl aminopeptidase 1

METAP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57 kDa and the accession number is P53582.

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METAP1 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	METAP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57 kDa and the accession number is P53582.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	P53582
别名	MAP1A, MetAP1A, methionyl aminopeptidase 1
蛋白构建	The N-terminal domain (Met 1-Phe 272) of Human METAP1 (NP_055958.2) was fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	57 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.

参考文献

1. Lowther, W.T. and B.W. Matthews, 2000, Biochim. Biophys. Acta. 1477: 157 – 167.2. Addlaqatta, A. et al., 2005, Biochemistry. 44: 14741-14749.3. Hu, X. et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103:18148-18153.

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Keywords

METAP1 Protein, Human, Recombinant (hFc) MAP1A MetAP1A methionyl aminopeptidase 1 recombinant recombinant-proteins proteins protein

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