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Cat. No.	Product Name	Target	Signaling Pathways
T14371	Barasertib 巴拉塞替,AZD1152	Apoptosis; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Barasertib (AZD1152) 是 Barasertib-hQPA 的前体药物，在癌细胞中诱导生长停滞和凋亡。它是高度选择性的Aurora B 抑制剂，IC50值为 0.37 nM。
T2602	Barasertib-HQPA 1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA\|AZD2811	Apoptosis; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B 抑制剂，在非细胞试验中IC50值为0.37 nM。它可阻滞癌细胞生长，诱导凋亡。
T36199	AZD 1152 (hydrochloride)
	AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p...