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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8921	M-31850 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-	Others	Others
	M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) 是一种竞争性的 β-己糖胺酶选择性抑制剂，能够抑制人HexA (IC50:6.0 µM) 及HexB (IC50:3.1 µM)。它还能够竞争性抑制 β-N-acetyl-D-hexosaminidaseOfHex2 (Ki:2.5 µM)。
T61135	β-N-Acetyl-D-hexosaminidase-IN-1	Others	Others
	β-N-Acetyl-D-hexosaminidase-IN-1 is a newly discovered chemical compound that acts as an inhibitor for β-N-acetyl-D-hexosaminidase. It exhibits a Ki value of 3.72 μM, indicating its potency in inhibiting the enzyme's activity.
T37193	4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside	Others	Others
	4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-μU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbellife...
T69914	Variegatic acid	Others	Others
	Variegatic acid is a natural inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL 2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively, also inhibiting PKC β1 activity with an IC50 value of 36.2 μM.
T38027	Ganglioside GM2 Asialo Mixture Ganglioside GM2 Asialo Mixture	Others	Others
	Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bact...
T83131	AMC-GlcNAc
	AMC-GlcNAc (compound 1) 作为一款高效荧光探针，主要用于β-己糖胺酶活性的检测与表征。该探针能在连续监测中开启荧光，并且在宽广pH值范围内维持稳定的荧光信号（Ex=325 nm, Em=390 nm）。AMC-GlcNAc还支持高灵敏度与低背景信号的比率荧光检测，适用于筛选大肠杆菌细胞裂解物中重组分散素B的活性。

化合物

M-31850

Cat.No: T8921

Synonym: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-

Target: Others

β-N-Acetyl-D-hexosaminidase-IN-1

Cat.No: T61135

Synonym:

Target: Others

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside

Ganglioside GM2 Asialo Mixture

Cat.No: T38027

Synonym: Ganglioside GM2 Asialo Mixture

Cat. No.	Product Name	Target	Signaling Pathways
TN3129	5-Nonadecylresorcinol	Others	Others
	5-Nonadecylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells.
TN3112	5-Heneicosylresorcinol	NADPH-oxidase; Antifection	Immunology/Inflammation; Microbiology/Virology
	5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用，它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。
T79977	Maceneolignan A	Others	Others
	Maceneolignan A，一种可从肉豆蔻（肉豆蔻科）假种皮分离的天然产品，有能力抑制RBL-2H3细胞内β-己糖胺酶释放，其IC50值为48.4 μM。同样，Maceneolignan A对抗原激活的RBL-2H3细胞中TNF-α释放的抑制作用，其IC50为63.7 μM。
TN7505	Thujopsene NSC 44707	Others	Others

T37272	9(S),12(S),13(S)-TriHOME	Others	Others
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...