Cat. No. | Product Name | Target | Signaling Pathways |
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T35499 |
β-Amyloid (1-42), (rat/mouse) (TFA)
Amyloid β-peptide (1-42) (human) TFA,166090-74-0 TFA |
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β-Amyloid (1-42), (rat/mouse) (TFA) 是由 42 个氨基酸组成的多肽片段,可用于研究阿尔茨海默症。 | |||
T35498 |
β-Amyloid (1-14),mouse,rat
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β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru... | |||
T39302 |
β-Amyloid (1-38), mouse, rat
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β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide. Notably, it serves as the primary constituent of amyloid plaques associated with Alzheimer's disease. | |||
TP1441 |
β-Amyloid (1-40) (rat)
Amyloid β-peptide (1-40) rat,β淀粉样肽(1-40)(鼠) |
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Rat form of the beta-Amyloid (1-40) peptide | |||
TP1230 |
β-Amyloid (1-42), (rat/mouse)
β-Amyloid (1-42), rat,Amyloid β-peptide (1-42) (rat) |
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Amyloid (1-42), rat is a polypeptide composed of 42 amino acids. It is toxic to hippocampal slices and can be used in the study of alzheimer's disease. | |||
TP1337 |
β-Amyloid (1-42), rat TFA
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β-Amyloid (1-42), rat TFA is a 42-aa peptide, shows the effects of cytotoxicity on acute hippocampal slices, and has been used in studies of alzheimer's disease. | |||
TP1733 |
Beta-Amyloid(1-14),mouse,rat
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Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. This peptide is amino acids 1 to 14 fragment of Beta-Amyloid peptide. | |||
T80701 |
β Amyloid (1-16) rat
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β-Amyloid (1-16) rat 是β-淀粉样肽 (Abeta) 金属结合域的片段,含有三个与人类相异的氨基酸替代,因此在大鼠和小鼠中降低了 AD 样神经退行性变的易感性。 | |||
TP1140L |
Neuropeptide Y (29-64), amide, human acetate
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Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Neuropeptide Y (29-64), amide, human acetate 参与阿尔茨海默病 (AD) 并保护大鼠皮质神经元免受 β-淀粉样蛋白毒性。 | |||
T15184 |
E 2012
(E)-1-[(1S)-1-(4-氟苯基)乙基]-3-[3-甲氧基-4-(4-甲基-1H-咪唑-1-YL)亚苄基]哌啶-2-酮 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
E 2012 是一种γ 分泌酶调节剂,不会影响 Notch 加工,在胆固醇生物合成的末步抑制 3β-羟基固醇 Δ24-还原酶。它能够减少淀粉样蛋白 β-42 减少阿兹海默氏病,并在大鼠多次重复给药后诱发白内障。 | |||
T37200 |
Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
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Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. It has been used to identify Aβ42 interaction partners in rat hippocampal synaptosomal membranes. | |||
T36446 |
Neuropeptide Y (human) (TFA)
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Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons. | |||
T75958 |
β-Amyloid (22-35) (TFA)
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β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA是β-淀粉样蛋白22-35残基段,具细胞毒性,能影响无血清培养大鼠海马神经元。在中性缓冲液中,此化合物能形成聚集体与典型淀粉样纤维,模拟β-淀粉样蛋白行为。 | |||
T31187 |
Dactylorhin B
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Dactylorhin B is an active compound isolated from Coeloglossum Viride. Dactylorhin B reduces the toxic effects of β -amyloid fragments (25-35) on neuron cells and isolated rat brain mitochondria, which play an important role in neurodegenerative diseases. | |||
TP1338 |
Neuropeptide Y (29-64), amide, human TFA
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Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t | |||
T75730 |
[D-Arg25]-Neuropeptide Y (human)
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[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是Y1受体的选择性激动剂。与阿尔茨海默病相关,该化合物能够保护老鼠皮质神经元免受淀粉样蛋白毒性的损害。 | |||
T37370 |
Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
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Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) and Aβ (1-42) fibrils. Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM.... | |||
TP1233 |
Amylin (8-37), rat
Amylin (8-37) (mouse, rat) |
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Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin fro | |||
T35608 |
16F16
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16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal ... |