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Cat. No. | Product Name | Target | Signaling Pathways |
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T27611 |
Ingenol 3-Hexanoate
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Ingenol 3-Hexanoate is a novel potent reactivator of latent HIV-1. | |||
T32162 |
Ingenol disoxate
LEO-43204,LEO43204,LEO 43204 |
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Ingenol disoxate, also known as LEO43204, is a Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties for Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers. Ingenol is a natural product found in the sap of the plant Euphor | |||
T124104 |
3-O-(2'E,4'Z-Decadienoyl)ingenol
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3-O-(2'E,4'Z-Decadienoyl)ingenol 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124104。 | |||
T124828 | 3-O-(2'E,4'E-Decadienoyl)ingenol | ||
3-O-(2'E,4'E-Decadienoyl)ingenol 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124828。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5S2017 |
Ingenol
(-)-Ingenol,巨大戟二萜醇,巨大戟醇 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Ingenol ((-)-Ingenol) 是一种PKC 激活剂,Ki 值为 30 μM,具有抗肿瘤活性。 从 Ingenol 酯中配制新的衍生物可能是开发新的先导化合物以重新激活潜伏 HIV 的创新方法。Ingenol mebutate 是治疗光化性角化病的有效方法。 | |||
TN1765 |
Ingenol-3,4,5,20-diacetonide
巨大戟醇-3,4:5,20-双缩丙酮,Ingenol-3,4:5,20-diacetonide |
Others | Others |
Ingenol-3,4,5,20-diacetonide 是从大戟植物的汁液中分离出来的一种天然产物,它被发现具有广泛的生物活性,包括抗肿瘤、抗炎和免疫调节作用。 | |||
TN1047 |
Ingenol mebutate
Ingenol 3-Angelate,巨大戟醇甲基丁烯酸酯,PEP005 |
gp120/CD4; HIV Protease; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Ingenol mebutate (Ingenol 3-Angelate) 是 PKC 的有效激动剂,包括 PKC-α、PKC-β、PKC-γ、PKC-δ 和 PKC-ε,Kis 为 0.3、0.105、0.162、0.376 和 0.171 nM。 Ingenol mebutate 具有抗炎和抗肿瘤活性。 | |||
TN1049 |
Ingenol-5,20-acetonide
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Others | Others |
Ingenol-5,20-acetonide 是一种天然化合物,Ingenol 3-Angelate 的类似物,当局部用于治疗光化性角化病时具有抗肿瘤活性。 | |||
TQ0316 |
Ingenol-5,20-acetonide-3-O-angelate
Ingenol 5,20-acetonide 3-angelate,Ingenol 3-angelate 5,20-acetonide,巨大戟醇-5,20-缩丙酮-3-当归酸酯 |
Others | Others |
Ingenol-5,20-acetonide-3-O-angelate (Ingenol 5,20-acetonide 3-angelate) 是一种天然产物。 | |||
TN4253 |
Ingenol 3-palmitate
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Others | Others |
Ingenol-3-palmitate shows irritant and cocarcinogenic activity on mouse ear and on mice back skin. | |||
TN4252 |
Ingenol 20-palmitate
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Others | Others |
Ingenol 20-palmitate is a natural product from Euphorbia sieboldiana. | |||
T35895 |
Ingenol 3,20-dibenzoate
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Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2]. | |||
TQ0164 |
Dodecanoic acid ingenol ester
正十二烷酸巨大戟酯,13-Oxyingenol dodecanoat |
Others | Others |
Dodecanoic acid ingenol ester, a natural compound, shows moderate cytotoxicity with IC50 values being 35.59 μM (Caco-2), 24.04 μM (MCF-7), and 22.24 μM (MCF-7/ADM). | |||
T83349 |
3-O-(2'E,4'E-Decadienoyl)-ingenol
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3-O-(2'E,4'E-Decadienoyl)-ingenol为天然二萜类化合物,对L-O2及GES-1人类正常细胞系表现出细胞毒性,其IC50值分别为8.22 μM与6.67 μM[1]。 | |||
TN2799 |
20-Deoxyingenol 3-angelate
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PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets, |