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Nectin-3 Protein, Human, Recombinant (hFc)

产品编号 TMPY-05495

别名: CDw113, FLJ90624, PVRL3, DKFZp566B0846, nectin-3, PRR3, CD113, PPR3, PVRR3, poliovirus receptor-related 3

Nectin-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.4 kDa and the accession number is Q9NQS3-1.

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Nectin-3 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized PVRL1/NECTIN1 Protein, Human, Recombinant (His Tag) at 2 μg/ml (100 μl/well) can bind Nectin 3 Protein, Human, Recombinant (ECD, hFc Tag), the EC50 of Nectin 3 Protein, Human, Recombinant (ECD, hFc Tag)is 30-140 ng/mL.
产品描述	Nectin-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.4 kDa and the accession number is Q9NQS3-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q9NQS3-1
别名	CDw113, FLJ90624, PVRL3, DKFZp566B0846, nectin-3, PRR3, CD113, PPR3, PVRR3, poliovirus receptor-related 3
蛋白构建	The Human NECTIN3 (NP_056295.1) (Met1-Asp400) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	64.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.

参考文献

1. Satoh-Horikawa,et al.(2000). Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem (UNITED STATES) . 275 (14): 10291-9. 2. Reymond N,et al.(2000). Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene (NETHERLANDS). 255 (2): 347-55.

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Keywords

Nectin-3 Protein, Human, Recombinant (hFc) DKFZp566B-0846 CDw113 FLJ90624 PVRL3 PVRL-3 PPR-3 PPR 3 DKFZp566B0846 nectin-3 PRR3 CD 113 DKFZp566B 0846 PVRR-3 CD113 PVRL 3 PRR-3 PPR3 FLJ 90624 PRR 3 CD-113 FLJ-90624 PVRR3 poliovirus receptor-related 3 PVRR 3 recombinant recombinant-proteins proteins protein

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