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Lactoferrin/LTF Protein, Human, Recombinant (His)

产品编号 TMPY-02188

别名: HEL110, LF, HLF2, GIG12, lactotransferrin

Lactoferrin/LTF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.5 kDa and the accession number is P02788.

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Lactoferrin/LTF Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	Lactoferrin/LTF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.5 kDa and the accession number is P02788.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P02788
别名	HEL110, LF, HLF2, GIG12, lactotransferrin
蛋白构建	The Human LTF (P02788) (Met 1-Lys 710) was expressed, fused with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	77.5 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Lactotransferrin, also known as Lactoferrin, Talalactoferrin, and LTF, is a secreted protein that belongs to the transferrin family. Transferrins are iron binding transport proteins that can bind two Fe3+ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B, and C have opioid antagonist activity. Lactoferrin A shows a preference for mu-receptors, while lactoferricin B and lactoferricin C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Lactoferrin / LTF is a globular glycoprotein that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin / LTF is also present in secondary granules of PMN and is secreted by some acinar cells. Lactoferrin / LTF can be purified from milk or produced recombinantly. Human colostrum has the highest concentration, followed by human milk, then cow milk. Lactoferrin / LTF is one of the components of the immune system of the body; it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucose. In particular, lactoferrin provides an antibacterial activity to human infants. Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands.

参考文献

1. Sánchez L, et al.,1992, Arch. Dis. Child. 67 (5): 657 - 61. 2. Wakabayashi H, et al., 2000, J. Antimicrob. Chemother. 46 (4): 595-602. 3. Nozaki A, et al., 2003, J. Biol. Chem. 278 (12): 10162-73. 4. Azzam HS, et al., 2007, Liver Int. 27 (1): 17-25.

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Keywords

Lactoferrin/LTF Protein, Human, Recombinant (His) GIG-12 HEL 110 HEL110 GIG 12 LF HEL-110 HLF2 HLF 2 GIG12 lactotransferrin HLF-2 recombinant recombinant-proteins proteins protein

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