IL-22BP Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.8 kDa and the accession number is Q969J5-2.
生物活性 | Testing in progress |
产品描述 | IL-22BP Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.8 kDa and the accession number is Q969J5-2. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | His, hFc |
蛋白编号 | Q969J5-2 |
别名 | interleukin 22 receptor, alpha 2, CRF2-S1, IL-22BP, interleukin 22 receptor, α2, IL-22RA2, IL-22R-alpha-2, ZCYTOR16, IL-22R-α-2, CRF2-10, CRF2X |
蛋白构建 | The Human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was fused with the C-terminal polyhistidine-tagged Fc region of Human IgG1 at the C-terminus. |
蛋白纯度 | > 90 % as determined by SDS-PAGE |
分子量 | 52.8 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type II cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in the placenta, spleen, breast, skin, and lung. It is also detected in the intestinal tract, testis, brain, heart, and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of the IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important role in the immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptors have been discovered, a membrane-bound receptor and a soluble receptor. |
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IL-22BP Protein, Human, Recombinant (His & hFc) interleukin 22 receptor, alpha 2 CRF2-S1 IL-22R-a-2 IL-22BP interleukin 22 receptor, α2 IL-22RA2 IL-22R-alpha-2 ZCYTOR 16 ZCYTOR16 ZCYTOR-16 IL-22R-α-2 CRF2-10 interleukin 22 receptor, a 2 interleukin 22 receptor, α 2 CRF2X recombinant recombinant-proteins proteins protein