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IL-12A Protein, Human, Recombinant (hFc)

IL-12A Protein, Human, Recombinant (hFc)

产品编号 TMPY-00838
别名: IL-12A, NKSF1, NFSK, CLMF, P35, interleukin 12A

IL-12A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is P29459.

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IL-12A Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
50 μg ¥ 2,940 5日内发货
1 mg ¥ 19,100 5日内发货
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产品目录号及名称: IL-12A Protein, Human, Recombinant (hFc) (TMPY-00838)
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生物活性 Testing in progress
产品描述 IL-12A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is P29459.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 P29459
别名 IL-12A, NKSF1, NFSK, CLMF, P35, interleukin 12A
蛋白构建 The p35 subunit of Human IL12, termed as IL12A (P29459) (Met 1-Ser 219) was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度 > 90 % as determined by SDS-PAGE
分子量 49.3 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Interleukin-12 subunit alpha (IL12A/IL-12p35) is also known as Cytotoxic lymphocyte maturation factor 35 kDa subunit, cytotoxic lymphocyte maturation factor 1, p35, NK cell stimulatory factor chain 1, and interleukin-12 alpha chain. IL12A/IL-12p35 is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A/IL-12p35 is required for the T-cell-independent induction of interferon (IFN)-gamma and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. In clinical, IL-12 remains a very promising immunotherapeutic agent because recent cancer vaccination studies in animal models and humans have demonstrated its powerful adjuvant properties. The immune-modulating characteristics of IL-12 considered responsible for the adjuvant effects, as well as the results of animal and human cancer vaccination studies with IL-12, applied as an adjuvant. IL12A/IL-12p35 indicates a cytokine that is important in the development of prostate cancer.

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Keywords

IL-12A Protein, Human, Recombinant (hFc) NKSF 1 IL-12A P 35 NKSF-1 NKSF1 NFSK CLMF P-35 P35 interleukin 12A recombinant recombinant-proteins proteins protein

 

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