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Dectin-1 Protein, Human, Recombinant (mFc)

产品编号 TMPY-00016

别名: CLECSF12, DECTIN1, C-type lectin domain family 7, member A, BGR, CANDF4

Dectin-1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.1 kDa and the accession number is Q9BXN2-2.

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Dectin-1 Protein, Human, Recombinant (mFc)

规格	价格/CNY		货期	数量
50 μg	￥ 2,270		5日内发货

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生物活性	Testing in progress
产品描述	Dectin-1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.1 kDa and the accession number is Q9BXN2-2.

种属	Human
表达系统	HEK293 Cells
标签	N-mFc
蛋白编号	Q9BXN2-2
别名	CLECSF12, DECTIN1, C-type lectin domain family 7, member A, BGR, CANDF4
蛋白构建	The Human CLEC7A (NP_072092.2) (Thr66-Met201) was expressed with the Fc region of Mouse IgG1 at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	42.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

参考文献

1. Herre J,et al.(2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203. 2. Sun L,et al.(2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64. 3. Schorey JS,et al.(2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9. 4. Reid DM,et al.(2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7. 5. Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.

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Keywords

Dectin-1 Protein, Human, Recombinant (mFc) CLECSF-12 CLECSF12 DECTIN1 DECTIN 1 DECTIN-1 C-type lectin domain family 7, member A BGR CANDF4 CANDF 4 CANDF-4 CLECSF 12 recombinant recombinant-proteins proteins protein

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