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CLEC-2 Protein, Human, Recombinant (His)

CLEC-2 Protein, Human, Recombinant (His)

产品编号 TMPY-02357
别名: C-type lectin domain family 1, member B, CLEC2B, 1810061I13Rik, PRO1384, CLEC2, QDED721

CLEC-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is Q9P126-1.

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CLEC-2 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 4,460 5日内发货
1 mg ¥ 29,100 5日内发货
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产品目录号及名称: CLEC-2 Protein, Human, Recombinant (His) (TMPY-02357)
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生物活性
技术参数
产品性质
参考文献
生物活性 1. Measured by its binding ability in a functional ELISA. 2. Immobilized human Podoplanin at 10 μg/mL (100 μl/well) can bind  biotinylated human CLEC1B-His, The EC50 of biotinylated human CLEC1B-His is 0.71 μg/mL.
产品描述 CLEC-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is Q9P126-1.
种属 Human
表达系统 HEK293 Cells
标签 N-His
蛋白编号 Q9P126-1
别名 C-type lectin domain family 1, member B, CLEC2B, 1810061I13Rik, PRO1384, CLEC2, QDED721
蛋白构建 Human CLEC1B (NP_057593.3) extracellular domain (Gln 58-Pro 229) with a N-terminal polyhistidine tag
蛋白纯度 > 76 % as determined by SDS-PAGE
分子量 22.7 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

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Keywords

CLEC-2 Protein, Human, Recombinant (His) C-type lectin domain family 1, member B CLEC2B 1810061I13Rik PRO1384 QDED 721 PRO 1384 CLEC-2 CLEC 2 QDED-721 PRO-1384 CLEC2 QDED721 recombinant recombinant-proteins proteins protein

 

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