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SNCA Protein, Mouse, Recombinant (His)

SNCA Protein, Mouse, Recombinant (His)

产品编号 TMPJ-00684   CAS TMPJ-00684
别名: Snca, Non-A β component of AD amyloid, Non-A4 component of amyloid precursor, α-synuclein, Alpha-synuclein, Non-A beta component of AD amyloid, NACP

Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important in the pathogenesis of neurodegenerative diseases. Alpha-synuclein is a dynamic molecule whose secondary structure depends on the environment. For example, it has an unfolded random coil structure in aqueous solution, forms a-helical structure upon binding to acidic phospholipid vesicles, and forms insoluble fibrils with a high b-sheet content that resemble the filaments found in Lewy bodies. Also, alpha-synuclein was known to associate with 14-3-3 proteins including protein kinase C, BAD, and extracellular regulated kinase, and overexpression of alpha-synuclein could contribute to cell death in neurodegenerative diseases.

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SNCA Protein, Mouse, Recombinant (His) Chemical Structure
SNCA Protein, Mouse, Recombinant (His), CAS TMPJ-00684
规格 价格/CNY 货期 数量
10 μg ¥ 1,170 5日内发货
50 μg ¥ 3,470 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货

SNCA Protein, Mouse, Recombinant (His) 的其他形式现货产品:

Alpha-Synuclein Protein, Human, Recombinant
产品目录号及名称: SNCA Protein, Mouse, Recombinant (His) (TMPJ-00684)
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产品描述 Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important in the pathogenesis of neurodegenerative diseases. Alpha-synuclein is a dynamic molecule whose secondary structure depends on the environment. For example, it has an unfolded random coil structure in aqueous solution, forms a-helical structure upon binding to acidic phospholipid vesicles, and forms insoluble fibrils with a high b-sheet content that resemble the filaments found in Lewy bodies. Also, alpha-synuclein was known to associate with 14-3-3 proteins including protein kinase C, BAD, and extracellular regulated kinase, and overexpression of alpha-synuclein could contribute to cell death in neurodegenerative diseases.
别名 Snca, Non-A β component of AD amyloid, Non-A4 component of amyloid precursor, α-synuclein, Alpha-synuclein, Non-A beta component of AD amyloid, NACP
分子量 18 KDa (reducing condition)
CAS No. TMPJ-00684

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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Keywords

SNCA Protein, Mouse, Recombinant (His) TMPJ-00684 Non-A b component of AD amyloid Snca Non-A β component of AD amyloid Non-A4 component of amyloid precursor α-synuclein Alpha-synuclein Non-A beta component of AD amyloid NACP a-synuclein Inhibitor inhibitor inhibit

 

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