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S100A8 Protein, Human, Recombinant (His)

S100A8 Protein, Human, Recombinant (His)

产品编号 TMPY-01356
别名: 60B8AG, MRP-8, MA387, NIF, L1Ag, S100 calcium binding protein A8, CFAG, MIF, P8, CP-10, MRP8, CGLA, CAGA

S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and cancer suggest that S100A8/A9 may play a key role in inflammation-associated cancer.

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S100A8 Protein, Human, Recombinant (His) Chemical Structure
S100A8 Protein, Human, Recombinant (His), CAS N/A
规格 价格/CNY 货期 数量
50 μg ¥ 2,230 现货
100 μg ¥ 3,820 5日内发货
200 μg ¥ 6,750 5日内发货
500 μg ¥ 14,280 5日内发货
产品目录号及名称: S100A8 Protein, Human, Recombinant (His) (TMPY-01356)
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纯度: 98.1%
纯度: 98.1%
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生物活性
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参考文献
产品描述 S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and cancer suggest that S100A8/A9 may play a key role in inflammation-associated cancer.
别名 60B8AG, MRP-8, MA387, NIF, L1Ag, S100 calcium binding protein A8, CFAG, MIF, P8, CP-10, MRP8, CGLA, CAGA
分子量 12.2 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Passey RJ,et al.(1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56. 2. Gebhardt C,et al.(2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31. 3. HAlayko AJ,et al.(2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55. 4. Ghavami S,et al.(2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83. 5. HA YS,et al.(2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.

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Keywords

S100A8 Protein, Human, Recombinant (His) 60B8AG CP10 MRP-8 MA 387 MA387 NIF L1Ag S100 calcium binding protein A8 CFAG MIF P8 CP-10 CP 10 P 8 MRP8 CGLA CAGA MA-387 P-8 MRP 8 Inhibitor inhibitor inhibit

 

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