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Granzyme B/GZMB Protein, Human, Recombinant (His)

Granzyme B/GZMB Protein, Human, Recombinant (His)

产品编号 TMPY-00817
别名: CGL1, CTLA1, CSP-B, CTSGL1, HLP, SECT, CSPB, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), CCPI, CGL-1

Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.

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Granzyme B/GZMB Protein, Human, Recombinant (His) Chemical Structure
Granzyme B/GZMB Protein, Human, Recombinant (His), CAS N/A
规格 价格/CNY 货期 数量
50 μg ¥ 3,820 现货
100 μg ¥ 6,530 5日内发货
200 μg ¥ 11,130 5日内发货
500 μg ¥ 22,510 5日内发货
产品目录号及名称: Granzyme B/GZMB Protein, Human, Recombinant (His) (TMPY-00817)
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纯度: SDS-PAGE: 96%; SEC-HPLC: 98.0%
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参考文献
产品描述 Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.
别名 CGL1, CTLA1, CSP-B, CTSGL1, HLP, SECT, CSPB, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), CCPI, CGL-1
分子量 27.2 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Schmid J.,et al.,(1987), Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J. Immunol. 139:250-256. 2. Caputo A.,et al., (1988), Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.J. Biol. Chem. 263:6363-6369. 3. Trapani J.A.,et al.,(1988), Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928.

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Keywords

Granzyme B/GZMB Protein, Human, Recombinant (His) CGL1 CTLA1 CSP-B CTLA 1 CTLA-1 CTSGL1 CTSGL-1 HLP SECT CSPB CTSGL 1 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) CCPI CGL 1 CGL-1 granzyme B Inhibitor inhibitor inhibit

 

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