Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,300 | 5日内发货 | ||
25 mg | ¥ 8,850 | 8-10周 | ||
50 mg | ¥ 11,500 | 8-10周 | ||
100 mg | ¥ 17,900 | 8-10周 |
UNC10217938A 的其他形式现货产品:
产品描述 | UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects. |
体外活性 | When UNC10217938A is used in the range of 5-25 μM, it can significantly enhance the induction of luciferase in HelaLuc705 cells, and it is more effective and more effective than Retro-1. Compared to a separate splice switch oligonucleotide (SSO), UNC10217938A provids a 60-fold enhancement at 10 μM and 220-fold at 20 μM, in contrast to a 11-fold enhancement for 100 μM Retro-1. UNC10217938A can substantially enhance effects of receptor targeted oligonucleotide conjugates. UNC10217938A can also enhance the effect of uncharged morpholino oligonucleotides and negatively charged oligonucleotides . Exposure of cells to UNC10217938A caused a significant reduction in the colocalization of TAMRA-oligonucleotides with the late ribosomal marker Rab7, but had little effect on the colocalization with the lysosomal marker LAMP-1. UNC10217938A causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation. |
分子量 | 456.54 |
分子式 | C26H28N6O2 |
CAS No. | 1347749-97-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
UNC10217938A 1347749-97-6 Others UNC-10217938A Inhibitor inhibitor inhibit