Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially available oxazolidinone antibiotic and is the prodrug form of tedizolid with a fixed once-daily dose. As an expanded-spectrum oxazolidinone, it has potent activity against a wide range of Gram-positive pathogens.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,113 | 待询 | ||
10 mg | ¥ 1,653 | 待询 | ||
50 mg | ¥ 4,713 | 待询 |
Tedizolid HCl (856866-72-3 free base) 的其他形式现货产品:
产品描述 | Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially available oxazolidinone antibiotic and is the prodrug form of tedizolid with a fixed once-daily dose. As an expanded-spectrum oxazolidinone, it has potent activity against a wide range of Gram-positive pathogens. |
体外活性 | In vitro, tedizolid was a reversible inhibitor for both human MAO-A and MAO-B; for MAO-A, the value of IC50 was 8.7 uM, and for MAO-B, the value of IC50 was 5.7 uM. For these two inhibitions, add 46.0 and 2.1 uM of linezolid, respectively would be better [2]. |
体内活性 | In vivo: It exhibited not only a potent activity against Gram-positive pathogens but also maintained activity against linezolid resistant bacteria. In the murine serotonergic model, the number of head twitches was analyzed after tedizolid phosphate was administrated by intraperitoneal injection [2]. |
别名 | Tedizolid HCl |
分子量 | 406.8 |
分子式 | C17H16ClFN6O3 |
CAS No. | T23451 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: > 13.57 mg/mL, Heating is recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tedizolid HCl (856866-72-3 free base) T23451 Others 856866-72-3 856866-72-3 free base Tedizolid HCl Tedizolid HCl (856866723 free base) Tedizolid HCl (856866 72 3 free base) Inhibitor inhibitor inhibit