Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
产品描述 | Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. |
体外活性 | The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM). |
体内活性 | In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively. |
别名 | HTI-286 trifluoroacetate, SPA-110 trifluoroacetate |
分子量 | 587.681 |
分子式 | C29H44F3N3O6 |
CAS No. | 228266-41-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 39 mg/mL (66.36 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7016 mL | 8.508 mL | 17.016 mL | 42.5401 mL |
5 mM | 0.3403 mL | 1.7016 mL | 3.4032 mL | 8.508 mL | |
10 mM | 0.1702 mL | 0.8508 mL | 1.7016 mL | 4.254 mL | |
20 mM | 0.0851 mL | 0.4254 mL | 0.8508 mL | 2.127 mL | |
50 mM | 0.034 mL | 0.1702 mL | 0.3403 mL | 0.8508 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Taltobulin trifluoroacetate 228266-41-9 Others SPA 110 Trifluoroacetate SPA110 Trifluoroacetate Taltobulin Trifluoroacetate SPA-110 Trifluoroacetate HTI-286 trifluoroacetate HTI 286 Trifluoroacetate HTI286 Trifluoroacetate HTI-286 Trifluoroacetate SPA-110 trifluoroacetate Inhibitor inhibitor inhibit