Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 μg | ¥ 1,690 | 35日内发货 | ||
1 mg | ¥ 3,220 | 35日内发货 | ||
5 mg | ¥ 13,500 | 35日内发货 |
产品描述 | Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM). |
靶点活性 | Vitamin D receptor:(kd)0.27 nM |
体外活性 | Seocalcitol is a stimulators of osteoclast recruitment in murine bone marrow cultures(EC50 at 0.1 nM). Seocalcitol stimulates bone resorption(EC50 of 0.03 nM)[1]. Seocalcitol elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC50=0.4±0.13). In the kidney, Kd values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the Kd for Seocalcitol is 1.43±0.19 nM)[2]. Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol than for 1 nM VD3. |
体内活性 | Seocalcitol is a synthetic vitamin D analog.Seocalcitol exhibits reduced hypercalcemic activity relative to 1,25(OH)2VD3. long-term intraperitoneal (IP) administration of Seocalcitol at a dose of 0.5 μg/kg body weight every other day in C3H/Sy mice exertes a very strong inhibitory effect on hepatocellular carcinoma (HCC) development[4]. Seocalcitol is administered daily to postnatal rats from 4 to 12 days of age (P4 to P12) by intraperitoneal injection at either 0.38 or 1.25 μg/kg body weight (BW)/day. Only the highest dose of Seocalcitol (1.25 μg/kg BW) causes a significant reduction in weight gain when administered alone or in conjunction with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid[5]. |
别名 | EB 1089 |
分子量 | 454.68 |
分子式 | C30H46O3 |
CAS No. | 134404-52-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.97 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1993 mL | 10.9967 mL | 21.9935 mL | 54.9837 mL |
5 mM | 0.4399 mL | 2.1993 mL | 4.3987 mL | 10.9967 mL | |
10 mM | 0.2199 mL | 1.0997 mL | 2.1993 mL | 5.4984 mL | |
20 mM | 0.11 mL | 0.5498 mL | 1.0997 mL | 2.7492 mL | |
50 mM | 0.044 mL | 0.2199 mL | 0.4399 mL | 1.0997 mL | |
100 mM | 0.022 mL | 0.11 mL | 0.2199 mL | 0.5498 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Seocalcitol 134404-52-7 Others EB 1089 EB1089 EB-1089 Inhibitor inhibitor inhibit