Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977)(IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | PSI-7409 tetrasodium, the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), exhibits specific inhibitory activity against NS5B polymerases of various genotypes, with IC50s being 1.6 μM for GT 1b_Con1, 2.8 μM for GT 2a_JFH1, 0.7 μM for GT 3a, and 2.6 μM for GT 4a, respectively. |
靶点活性 | GT2a JFH1:2.8 μM , GT3a:0.7 μM , GT4a:2.6 μM , GT1b Con1:1.6 μM |
体外活性 | The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1]. |
分子量 | 592.117 |
分子式 | C10H16FN2Na4O14P3 |
CAS No. | 1621884-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 125 mg/mL (211.11 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 1.6889 mL | 8.4443 mL | 16.8886 mL | 42.2214 mL |
5 mM | 0.3378 mL | 1.6889 mL | 3.3777 mL | 8.4443 mL | |
10 mM | 0.1689 mL | 0.8444 mL | 1.6889 mL | 4.2221 mL | |
20 mM | 0.0844 mL | 0.4222 mL | 0.8444 mL | 2.1111 mL | |
50 mM | 0.0338 mL | 0.1689 mL | 0.3378 mL | 0.8444 mL | |
100 mM | 0.0169 mL | 0.0844 mL | 0.1689 mL | 0.4222 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PSI-7409 tetrasodium 1621884-22-7 Others PSI 7409 PSI7409 PSI 7409 tetrasodium PSI-7409 PSI7409 tetrasodium Inhibitor inhibitor inhibit