Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,400 | 6-8周 |
产品描述 | PDE2/PDE10-IN-1 is a inhibitor of phosphodiesterase 2 (PDE2) and PDE10(IC50s of 29 and 480 nM, respectively). |
靶点活性 | PDE11A (human):6920 nM, PDE4D (human):5890 nM, PDE10A (rat):480 nM, PDE2A (human):29 nM |
体外活性 | PDE2/PDE10-IN-1 inhibits PDE2 and PDE10(IC50 of 29 and 480 nM, respectively). PDE2/PDE10-IN-1 is also inactive up to a concentration of 125 μg/mL in a bacterial mutagenicity assay. PDE2/PDE10-IN-1 also inhibits PDE11A and PDE4D with IC50s of 6920 nM and 5890 nM, respectively. In addition PDE2/PDE10-IN-1 does not show significant inhibition of a panel of CYP450 enzymes (CYP1A2, 2C9, 2D6, 2C19, and 3A4). |
体内活性 | PDE2/PDE10-IN-1, which is orally bioavailable, occupies PDE2 with an ED50 of 21 mg/kg. |
分子量 | 295.73 |
分子式 | C15H10ClN5 |
CAS No. | 1426833-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PDE2/PDE10-IN-1 1426833-08-0 Others PDE2/PDE10 IN 1 PDE-2/PDE10-IN-1 PDE2/PDE10IN1 Inhibitor inhibitor inhibit