Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Methylmoranoline is an inhibitor of α-glucosidase.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 μg | ¥ 1,080 | 35日内发货 | ||
1 mg | ¥ 1,900 | 35日内发货 | ||
5 mg | ¥ 8,340 | 35日内发货 |
产品描述 | N-Methylmoranoline is an inhibitor of α-glucosidase. |
体内活性 | N-Methylmoranoline(MOR-14) dose-dependently decreased the alpha-1,6-glucosidase activity in rabbit heart extract.?The myocardial uptake of a considerable amount of MOR-14 sufficient to fully inhibit alpha-1,6-glucosidase.?To assess the infarct size-reducing effect of MOR-14, 54 rabbits were subjected to 30-minute coronary occlusion followed by 48-hour reperfusion.?Preischemic treatment with 25, 50, and 100 mg/kg of MOR-14 dose-dependently reduced the infarct size (to 26+/-4%, 19+/-3%, and 14+/-2% of the area at risk, respectively), compared with the saline control (45+/-5%) without altering the blood pressure or heart rate.?Another 40 rabbits given 100 mg of MOR-14 or saline 10 minutes before ischemia were euthanized at 10 or 30 minutes of ischemia for biochemical analysis.?MOR-14 decreased the alpha-1,6-glucosidase activity to approximately 20% in vivo, reduced the glycogen breakdown, and attenuated the lactate accumulation at both 10 and 30 minutes of ischemia[1]. |
别名 | MOR 14, N-Methyl-1-deoxynojirimycin, N-Methylmoranolin |
分子量 | 177.2 |
分子式 | C7H15NO4 |
CAS No. | 69567-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
N-Methylmoranoline 69567-10-8 Others MOR 14 N-Methyl-1-deoxynojirimycin NMethylmoranoline N-Methylmoranolin MOR-14 N Methylmoranoline MOR14 Inhibitor inhibitor inhibit