Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 542 | 5日内发货 | ||
5 mg | ¥ 1,090 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,130 | 5日内发货 |
产品描述 | MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively). |
体外活性 | MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme, in rodent species. mPGES-1 MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. The compound selectively inhibited the synthesis of PGE(2) when tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. |
分子量 | 378.81 |
分子式 | C23H11ClN4 |
CAS No. | 892549-43-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43 mg/mL (113.51 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6398 mL | 13.1992 mL | 26.3985 mL | 65.9961 mL |
5 mM | 0.528 mL | 2.6398 mL | 5.2797 mL | 13.1992 mL | |
10 mM | 0.264 mL | 1.3199 mL | 2.6398 mL | 6.5996 mL | |
20 mM | 0.132 mL | 0.66 mL | 1.3199 mL | 3.2998 mL | |
50 mM | 0.0528 mL | 0.264 mL | 0.528 mL | 1.3199 mL | |
100 mM | 0.0264 mL | 0.132 mL | 0.264 mL | 0.66 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MF63 892549-43-8 Others MF-63 MF 63 Inhibitor inhibitor inhibit