Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,980 | 现货 | ||
5 mg | ¥ 4,920 | 现货 | ||
10 mg | ¥ 7,130 | 现货 | ||
25 mg | ¥ 10,600 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 |
产品描述 | KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation). |
体外活性 | KP136 (0.01 μg/mL) inhibits this histamine release and degranulation in a dose-dependent manner. This confirms it is an inhibitor of mast cell activation[1]. |
体内活性 | KP136 (1 mg/kg, i.v.) also remarkably inhibits 5-h homologous PCA, having an activity similar to that of C4C. C4C at 0.2 mg/kg produces an equipotent effect to 1 mg/kg KP136 or 5 mg/kg DSCG. However, C4C is less effective by the oral route because it only produces a maximum inhibition of about 35% even at the high dose of 100 mg/kg, whereas KP136 displays an overt inhibitory effect of about 66% at the oral dose of 2 mg/kg [1]. |
别名 | AL136 |
分子量 | 314.34 |
分子式 | C16H18N4O3 |
CAS No. | 76239-32-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KP136 76239-32-2 Others AL 136 KP-136 AL-136 KP 136 AL136 Inhibitor inhibitor inhibit