首页工具

购物车

Imisopasem manganese

产品编号 T7348 CAS 218791-21-0

别名: M40403, 伊米帕锰

Imisopasem manganese (M40403) is a manganese superoxide MnSOD non-peptidyl mimetic.

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

Imisopasem manganese, CAS 218791-21-0

规格	价格/CNY	货期
2 mg	￥ 813	5日内发货
5 mg	￥ 1,390	5日内发货
25 mg	￥ 5,380	6-8周
50 mg	￥ 6,990	6-8周
100 mg	￥ 9,570	6-8周

大包装超大折扣，点击咨询

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Imisopasem manganese (M40403) is a manganese superoxide MnSOD non-peptidyl mimetic.
体外活性	M40403 removes superoxide anions without interfering with other reactive species known to be involved in inflammatory responses (e.g. nitric oxide, NO and peroxynitrite)[1].
体内活性	M40403 has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. M40403 inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by M40403 except for NOx, PGE2 and IL-10 which remains unaltered [1]. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the M40403 pre-treated mice [2].
动物实验	Rats: Male Sprague-Dawley rats are used in the study. M40403 (5-20?mg?kg-1), or an equivalent volume (0.3?mL) of the vehicle (26?mm sodium bicarbonate buffer, pH?8.1-8.3), is injected intraperitoneally (i.p.) 15?min before carrageenan. At 4?h after the injection of carrageenan, the animals are killed by inhalation of CO2 [1]. Mice: 30 mg dry powder M40403 is dissolved in 6.0 ml SBC adjusted to pH 8.3 with 1 M NaOH. This stock solution is diluted to 1.25 mg/mL in SBC. Two experimental models are tested. In one, the dose of IR is held constant at 8.5 Gy total body irradiation (TBI). The mice are injected i.p. with a single dose of 40 mg/kg, 30 mg/kg, 20 mg/kg or 10 mg/kg M40403. Thirty minutes later the mice receive 8.5 Gy total body irradiation (TBI). Control animals received 0.1 ml of SBC buffer prior to TBI. In the other model, groups of 20 mice receive either 6.5 or 7.5 Gy TBI. One half of each group is treated with 2.0 mg/kg M40403 i.p. and the other with SBC 30 min before TBI [2].

别名	M40403, 伊米帕锰
分子量	483.38
分子式	C21H35Cl2MnN5
CAS No.	218791-21-0

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 15 mg/mL (27.86 mM), Sonication and heating are recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O	1 mM	2.0688 mL	10.3438 mL	20.6877 mL	51.7191 mL
	5 mM	0.4138 mL	2.0688 mL	4.1375 mL	10.3438 mL
	10 mM	0.2069 mL	1.0344 mL	2.0688 mL	5.1719 mL
	20 mM	0.1034 mL	0.5172 mL	1.0344 mL	2.586 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27. 2. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +